Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum

Endoplasmic reticulum (ER) dysfunction is important for alpha-synuclein (αS) acquired toxicity. When targeted to the ER in SH-SY5Y cells, transient or stable expression of αS resulted in the formation of compact αS-positive structures in a small subpopulation of cells, resembling αS inclusions. Thus...

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Detalles Bibliográficos
Autores principales: Miraglia, Fabiana, Valvano, Verdiana, Rota, Lucia, Di Primio, Cristina, Quercioli, Valentina, Betti, Laura, Giannaccini, Gino, Cattaneo, Antonino, Colla, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460339/
https://www.ncbi.nlm.nih.gov/pubmed/32796544
http://dx.doi.org/10.3390/life10080147

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