Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102

Two new benzofurans, alternabenzofurans A and B (1 and 2) and two new sesquiterpenoids, alternaterpenoids A and B (3 and 4), along with 18 known polyketides (5−22), were isolated from the marine-derived fungus Alternaria sp. 5102. Their structures were elucidated on the basis of extensive spectrosco...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Senhua, Deng, Yanlian, Yan, Chong, Wu, Zhenger, Guo, Heng, Liu, Lan, Liu, Hongju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460390/
https://www.ncbi.nlm.nih.gov/pubmed/32823987
http://dx.doi.org/10.3390/md18080426
_version_ 1783576590408482816
author Chen, Senhua
Deng, Yanlian
Yan, Chong
Wu, Zhenger
Guo, Heng
Liu, Lan
Liu, Hongju
author_facet Chen, Senhua
Deng, Yanlian
Yan, Chong
Wu, Zhenger
Guo, Heng
Liu, Lan
Liu, Hongju
author_sort Chen, Senhua
collection PubMed
description Two new benzofurans, alternabenzofurans A and B (1 and 2) and two new sesquiterpenoids, alternaterpenoids A and B (3 and 4), along with 18 known polyketides (5−22), were isolated from the marine-derived fungus Alternaria sp. 5102. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-ESIMS, and ECD) and X-ray crystallography, as well as the modified Mosher’s method. Compounds 2, 3, 5, 7, 9–18, and 20–22 exhibited potent anti-inflammatory activity by inhibiting the production of NO in RAW264.7 cells activated by lipopolysaccharide with IC(50) values in the range from 1.3 to 41.1 μM. Structure-activity relationships of the secondary metabolites were discussed.
format Online
Article
Text
id pubmed-7460390
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74603902020-09-02 Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102 Chen, Senhua Deng, Yanlian Yan, Chong Wu, Zhenger Guo, Heng Liu, Lan Liu, Hongju Mar Drugs Article Two new benzofurans, alternabenzofurans A and B (1 and 2) and two new sesquiterpenoids, alternaterpenoids A and B (3 and 4), along with 18 known polyketides (5−22), were isolated from the marine-derived fungus Alternaria sp. 5102. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-ESIMS, and ECD) and X-ray crystallography, as well as the modified Mosher’s method. Compounds 2, 3, 5, 7, 9–18, and 20–22 exhibited potent anti-inflammatory activity by inhibiting the production of NO in RAW264.7 cells activated by lipopolysaccharide with IC(50) values in the range from 1.3 to 41.1 μM. Structure-activity relationships of the secondary metabolites were discussed. MDPI 2020-08-14 /pmc/articles/PMC7460390/ /pubmed/32823987 http://dx.doi.org/10.3390/md18080426 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Senhua
Deng, Yanlian
Yan, Chong
Wu, Zhenger
Guo, Heng
Liu, Lan
Liu, Hongju
Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102
title Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102
title_full Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102
title_fullStr Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102
title_full_unstemmed Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102
title_short Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102
title_sort secondary metabolites with nitric oxide inhibition from marine-derived fungus alternaria sp. 5102
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460390/
https://www.ncbi.nlm.nih.gov/pubmed/32823987
http://dx.doi.org/10.3390/md18080426
work_keys_str_mv AT chensenhua secondarymetaboliteswithnitricoxideinhibitionfrommarinederivedfungusalternariasp5102
AT dengyanlian secondarymetaboliteswithnitricoxideinhibitionfrommarinederivedfungusalternariasp5102
AT yanchong secondarymetaboliteswithnitricoxideinhibitionfrommarinederivedfungusalternariasp5102
AT wuzhenger secondarymetaboliteswithnitricoxideinhibitionfrommarinederivedfungusalternariasp5102
AT guoheng secondarymetaboliteswithnitricoxideinhibitionfrommarinederivedfungusalternariasp5102
AT liulan secondarymetaboliteswithnitricoxideinhibitionfrommarinederivedfungusalternariasp5102
AT liuhongju secondarymetaboliteswithnitricoxideinhibitionfrommarinederivedfungusalternariasp5102

Ejemplares similares