Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing

Osimertinib, which is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is an important anticancer drug because of its high efficacy and excellent safety profile. However, resistance against osimertinib is inevitable; therefore, therapeutic strategies to overcome the res...

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Detalles Bibliográficos
Autores principales: Suzuki, Shuhei, Yamamoto, Masahiro, Sanomachi, Tomomi, Togashi, Keita, Sugai, Asuka, Seino, Shizuka, Okada, Masashi, Yoshioka, Takashi, Kitanaka, Chifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460424/
https://www.ncbi.nlm.nih.gov/pubmed/32764319
http://dx.doi.org/10.3390/biomedicines8080273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460424/
https://www.ncbi.nlm.nih.gov/pubmed/32764319
http://dx.doi.org/10.3390/biomedicines8080273

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