B-Mode and Contrast Enhanced Ultrasonography Features of Gastric Inflammatory and Neoplastic Diseases in Cats

SIMPLE SUMMARY: Alimentary lymphoma is the most common neoplasm of the feline gastrointestinal tract. In most cases, standard ultrasonography may not be able to discriminate between a neoplastic and inflammatory infiltrate at this level. The aim of this prospective study is to establish the value of conventional ultrasound and contrast enhanced ultrasonography in describing specific features of normal, inflammatory, and neoplastic gastric diseases in feline species. A total of 29 cats were included in the study: six healthy cats as the control group; nine with gastric inflammation; three with low-grade alimentary lymphoma; 10 with high grade alimentary lymphoma. High-grade lymphoma usually appears as a severe wall thickening with absent layer definition, regional lymphadenopathy and local steatitis on a conventional ultrasound and shows a high-contrast uptake and a homogeneous enhancement with comb teeth-like vessels on contrast-enhanced ultrasound, while gastric inflammation and low-grade alimentary lymphoma showed a large overlap on both of those two ultrasonographic techniques. Diagnostic accuracy and cut-off value were calculated and found to be relevant for thickness (3.8 mm) for inflammation vs. low-grade lymphoma and “benign” vs. “malignant” as well as peak enhancement (34.87 dB) for “benign” vs. “malignant”. Thickness and peak enhancement can be useful parameters in the characterization of gastric infiltrates in cats. ABSTRACT: Alimentary lymphoma (AL) is the most common malignancy of the feline gastrointestinal tract and may cause variable mild to severe alteration of the gastric wall on ultrasonography (US) that can be very similar to those caused by inflammation (INF). The aim of this prospective study is to establish the value of B-mode and contrast-enhanced US (CEUS) in describing specific features of normal, inflammatory, and neoplastic gastric diseases in feline species. B-mode US and CEUS of the stomach were performed in anesthetized cats with or without gastric disorders. Gastric wall qualitative and quantitative parameters were evaluated on B-mode US and CEUS examination. A total of 29 cats were included: six healthy (HEA) cats as the control group; nine INF; three low-grade lymphoma (LGAL); 10 high-grade lymphoma (HGAL). On B-mode US, there were significant differences in thickness, the wall’s layer definition and echogenicity between HGAL and all the other groups (<0.001). For CEUS, statistical differences between groups were found in the following: HGAL vs. HEA, HGAL vs. INF; HGAL vs. LGAL; INF vs. HEA. Diagnostic accuracy (AUC) and cut-off value were calculated and found to be significant for thickness (3.8 mm) for INF vs. LGAL (AUC > 0.70) and “benign” vs. “malignant” (AUC > 0.90) as well as peak enhancement (34.87 dB) for “benign” vs. “malignant” (AUC > 0.70). INF and LGAL showed an overlap of qualitative and quantitative parameters both on B-mode and CEUS, while HGAL usually appears as a severe wall thickening with absent layer definition, high-contrast uptake, a specific enhancement pattern, regional lymphadenopathy and local steatitis. Thickness and peak enhancement can be useful parameters in the characterization of gastric infiltrates in cats.