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Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance

The unprecedented use of antibiotics that led to development of resistance affect human health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases progressed with the acquisition and as such development of antibiotic resistant microbes that led to the resurgence...

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Autores principales: AlSheikh, Hana Mohammed Al, Sultan, Insha, Kumar, Vijay, Rather, Irfan A., Al-Sheikh, Hashem, Tasleem Jan, Arif, Haq, Qazi Mohd Rizwanul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460449/
https://www.ncbi.nlm.nih.gov/pubmed/32759771
http://dx.doi.org/10.3390/antibiotics9080480
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author AlSheikh, Hana Mohammed Al
Sultan, Insha
Kumar, Vijay
Rather, Irfan A.
Al-Sheikh, Hashem
Tasleem Jan, Arif
Haq, Qazi Mohd Rizwanul
author_facet AlSheikh, Hana Mohammed Al
Sultan, Insha
Kumar, Vijay
Rather, Irfan A.
Al-Sheikh, Hashem
Tasleem Jan, Arif
Haq, Qazi Mohd Rizwanul
author_sort AlSheikh, Hana Mohammed Al
collection PubMed
description The unprecedented use of antibiotics that led to development of resistance affect human health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases progressed with the acquisition and as such development of antibiotic resistant microbes that led to the resurgence of pathogenic strains harboring enhanced armors against existing therapeutics. Compromised the treatment regime of a broad range of antibiotics, rise in resistance has threatened human health and increased the treatment cost of diseases. Diverse on metabolic, genetic and physiological fronts, rapid progression of resistant microbes and the lack of a strategic management plan have led researchers to consider plant-derived substances (PDS) as alternative or in complementing antibiotics against the diseases. Considering the quantitative characteristics of plant constituents that attribute health beneficial effects, analytical procedures for their isolation, characterization and phytochemical testing for elucidating ethnopharmacological effects has being worked out for employment in the treatment of different diseases. With an immense potential to combat bacterial infections, PDSs such as polyphenols, alkaloids and tannins, present a great potential for use, either as antimicrobials or as antibiotic resistance modifiers. The present study focuses on the mechanisms by which PDSs help overcome the surge in resistance, approaches for screening different phytochemicals, methods employed in the identification of bioactive components and their testing and strategies that could be adopted for counteracting the lethal consequences of multidrug resistance.
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spelling pubmed-74604492020-09-03 Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance AlSheikh, Hana Mohammed Al Sultan, Insha Kumar, Vijay Rather, Irfan A. Al-Sheikh, Hashem Tasleem Jan, Arif Haq, Qazi Mohd Rizwanul Antibiotics (Basel) Review The unprecedented use of antibiotics that led to development of resistance affect human health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases progressed with the acquisition and as such development of antibiotic resistant microbes that led to the resurgence of pathogenic strains harboring enhanced armors against existing therapeutics. Compromised the treatment regime of a broad range of antibiotics, rise in resistance has threatened human health and increased the treatment cost of diseases. Diverse on metabolic, genetic and physiological fronts, rapid progression of resistant microbes and the lack of a strategic management plan have led researchers to consider plant-derived substances (PDS) as alternative or in complementing antibiotics against the diseases. Considering the quantitative characteristics of plant constituents that attribute health beneficial effects, analytical procedures for their isolation, characterization and phytochemical testing for elucidating ethnopharmacological effects has being worked out for employment in the treatment of different diseases. With an immense potential to combat bacterial infections, PDSs such as polyphenols, alkaloids and tannins, present a great potential for use, either as antimicrobials or as antibiotic resistance modifiers. The present study focuses on the mechanisms by which PDSs help overcome the surge in resistance, approaches for screening different phytochemicals, methods employed in the identification of bioactive components and their testing and strategies that could be adopted for counteracting the lethal consequences of multidrug resistance. MDPI 2020-08-04 /pmc/articles/PMC7460449/ /pubmed/32759771 http://dx.doi.org/10.3390/antibiotics9080480 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
AlSheikh, Hana Mohammed Al
Sultan, Insha
Kumar, Vijay
Rather, Irfan A.
Al-Sheikh, Hashem
Tasleem Jan, Arif
Haq, Qazi Mohd Rizwanul
Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance
title Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance
title_full Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance
title_fullStr Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance
title_full_unstemmed Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance
title_short Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance
title_sort plant-based phytochemicals as possible alternative to antibiotics in combating bacterial drug resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460449/
https://www.ncbi.nlm.nih.gov/pubmed/32759771
http://dx.doi.org/10.3390/antibiotics9080480
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