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FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan
Fibroblast growth factor receptor 4 (FGFR4) is involved in multiple physiological and pathological processes. Several genetic variants of FGFR4 have been shown to be associated with tumor progression in many cancers. However, its association, such as genetic variants and expression levels, with lung...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460457/ https://www.ncbi.nlm.nih.gov/pubmed/32781755 http://dx.doi.org/10.3390/ijerph17165694 |
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author | Li, Ju-Pi Huang, Hsien-Cheng Yang, Po-Jen Chang, Chien-Yuan Chao, Yu-Hua Tsao, Thomas Chang-Yao Huang, Hsuan Hung, Yu-Ching Hsieh, Ming-Ju Yang, Shun-Fa |
author_facet | Li, Ju-Pi Huang, Hsien-Cheng Yang, Po-Jen Chang, Chien-Yuan Chao, Yu-Hua Tsao, Thomas Chang-Yao Huang, Hsuan Hung, Yu-Ching Hsieh, Ming-Ju Yang, Shun-Fa |
author_sort | Li, Ju-Pi |
collection | PubMed |
description | Fibroblast growth factor receptor 4 (FGFR4) is involved in multiple physiological and pathological processes. Several genetic variants of FGFR4 have been shown to be associated with tumor progression in many cancers. However, its association, such as genetic variants and expression levels, with lung cancer is controversial. The present study examined the relationship between four single-nucleotide polymorphisms (SNPs; rs2011077 T/C, rs351855 G/A, rs7708357 G/A, and rs1966265 A/G) of FGFR4 and the risk of lung adenocarcinoma with the epidermal growth factor receptor (EGFR) mutation status in a Taiwanese cohort. The results demonstrated that FGFR4 rs2011077 (odds ratio (OR) = 0.348, 95% confidence interval (CI) = 0.136–0.891, p = 0.024), and rs351855 (OR = 0.296, 95% CI = 0.116–0.751, p = 0.008) showed an inverse association with distant metastasis in wild-type EGFR lung adenocarcinoma. Furthermore, a database analysis using The Cancer Genome Atlas revealed that the higher FGFR4 expression level was correlated with poor survival rates in wild-type EGFR lung adenocarcinoma. In conclusion, the data suggest that FGFR4 SNPs may help in identifying patient subgroups at low-risk for tumor metastasis, among carriers of lung adenocarcinoma bearing wild-type EGFR. |
format | Online Article Text |
id | pubmed-7460457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74604572020-09-03 FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan Li, Ju-Pi Huang, Hsien-Cheng Yang, Po-Jen Chang, Chien-Yuan Chao, Yu-Hua Tsao, Thomas Chang-Yao Huang, Hsuan Hung, Yu-Ching Hsieh, Ming-Ju Yang, Shun-Fa Int J Environ Res Public Health Article Fibroblast growth factor receptor 4 (FGFR4) is involved in multiple physiological and pathological processes. Several genetic variants of FGFR4 have been shown to be associated with tumor progression in many cancers. However, its association, such as genetic variants and expression levels, with lung cancer is controversial. The present study examined the relationship between four single-nucleotide polymorphisms (SNPs; rs2011077 T/C, rs351855 G/A, rs7708357 G/A, and rs1966265 A/G) of FGFR4 and the risk of lung adenocarcinoma with the epidermal growth factor receptor (EGFR) mutation status in a Taiwanese cohort. The results demonstrated that FGFR4 rs2011077 (odds ratio (OR) = 0.348, 95% confidence interval (CI) = 0.136–0.891, p = 0.024), and rs351855 (OR = 0.296, 95% CI = 0.116–0.751, p = 0.008) showed an inverse association with distant metastasis in wild-type EGFR lung adenocarcinoma. Furthermore, a database analysis using The Cancer Genome Atlas revealed that the higher FGFR4 expression level was correlated with poor survival rates in wild-type EGFR lung adenocarcinoma. In conclusion, the data suggest that FGFR4 SNPs may help in identifying patient subgroups at low-risk for tumor metastasis, among carriers of lung adenocarcinoma bearing wild-type EGFR. MDPI 2020-08-06 2020-08 /pmc/articles/PMC7460457/ /pubmed/32781755 http://dx.doi.org/10.3390/ijerph17165694 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Ju-Pi Huang, Hsien-Cheng Yang, Po-Jen Chang, Chien-Yuan Chao, Yu-Hua Tsao, Thomas Chang-Yao Huang, Hsuan Hung, Yu-Ching Hsieh, Ming-Ju Yang, Shun-Fa FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan |
title | FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan |
title_full | FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan |
title_fullStr | FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan |
title_full_unstemmed | FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan |
title_short | FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan |
title_sort | fgfr4 gene polymorphism reduces the risk of distant metastasis in lung adenocarcinoma in taiwan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460457/ https://www.ncbi.nlm.nih.gov/pubmed/32781755 http://dx.doi.org/10.3390/ijerph17165694 |
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