Arginine and Endothelial Function

Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial functio...

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Detalles Bibliográficos
Autores principales: Gambardella, Jessica, Khondkar, Wafiq, Morelli, Marco Bruno, Wang, Xujun, Santulli, Gaetano, Trimarco, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460461/
https://www.ncbi.nlm.nih.gov/pubmed/32781796
http://dx.doi.org/10.3390/biomedicines8080277
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author Gambardella, Jessica
Khondkar, Wafiq
Morelli, Marco Bruno
Wang, Xujun
Santulli, Gaetano
Trimarco, Valentina
author_facet Gambardella, Jessica
Khondkar, Wafiq
Morelli, Marco Bruno
Wang, Xujun
Santulli, Gaetano
Trimarco, Valentina
author_sort Gambardella, Jessica
collection PubMed
description Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.
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spelling pubmed-74604612020-09-03 Arginine and Endothelial Function Gambardella, Jessica Khondkar, Wafiq Morelli, Marco Bruno Wang, Xujun Santulli, Gaetano Trimarco, Valentina Biomedicines Review Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus. MDPI 2020-08-06 /pmc/articles/PMC7460461/ /pubmed/32781796 http://dx.doi.org/10.3390/biomedicines8080277 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gambardella, Jessica
Khondkar, Wafiq
Morelli, Marco Bruno
Wang, Xujun
Santulli, Gaetano
Trimarco, Valentina
Arginine and Endothelial Function
title Arginine and Endothelial Function
title_full Arginine and Endothelial Function
title_fullStr Arginine and Endothelial Function
title_full_unstemmed Arginine and Endothelial Function
title_short Arginine and Endothelial Function
title_sort arginine and endothelial function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460461/
https://www.ncbi.nlm.nih.gov/pubmed/32781796
http://dx.doi.org/10.3390/biomedicines8080277
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