Involvement of Reactive Oxygen Species in the Hepatorenal Toxicity of Actinomycin V In Vitro and In Vivo

The high toxicity of actinomycin D (Act D) severely limits its use as a first-line chemotherapeutic agent in the clinic. Actinomycin V (Act V), an analog of Act D, exhibited strong anticancer activity in our previous studies. Here, we provide evidence that Act V has less hepatorenal toxicity than Ac...

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Detalles Bibliográficos
Autores principales: Jia, Fu-juan, Han, Zhuo, Ma, Jia-hui, Jiang, Shi-qing, Zhao, Xing-ming, Ruan, Hang, Xie, Wei-dong, Li, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460479/
https://www.ncbi.nlm.nih.gov/pubmed/32824227
http://dx.doi.org/10.3390/md18080428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460479/
https://www.ncbi.nlm.nih.gov/pubmed/32824227
http://dx.doi.org/10.3390/md18080428

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