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Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908)
Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q–T (1–4). The structures of new metabolites 1–4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducibl...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460508/ https://www.ncbi.nlm.nih.gov/pubmed/32722176 http://dx.doi.org/10.3390/md18080383 |
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| author | Zhang, Yi-Lin Chiang, Chih-Chao Lee, Yi-Ting Wen, Zhi-Hong Wu, Yang-Chang Wu, Yu-Jen Hwang, Tsong-Long Wu, Tung-Ying Chang, Chia-Yuan Sung, Ping-Jyun |
| author_facet | Zhang, Yi-Lin Chiang, Chih-Chao Lee, Yi-Ting Wen, Zhi-Hong Wu, Yang-Chang Wu, Yu-Jen Hwang, Tsong-Long Wu, Tung-Ying Chang, Chia-Yuan Sung, Ping-Jyun |
| author_sort | Zhang, Yi-Lin |
| collection | PubMed |
| description | Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q–T (1–4). The structures of new metabolites 1–4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS). |
| format | Online Article Text |
| id | pubmed-7460508 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74605082020-09-03 Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908) Zhang, Yi-Lin Chiang, Chih-Chao Lee, Yi-Ting Wen, Zhi-Hong Wu, Yang-Chang Wu, Yu-Jen Hwang, Tsong-Long Wu, Tung-Ying Chang, Chia-Yuan Sung, Ping-Jyun Mar Drugs Article Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q–T (1–4). The structures of new metabolites 1–4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS). MDPI 2020-07-24 /pmc/articles/PMC7460508/ /pubmed/32722176 http://dx.doi.org/10.3390/md18080383 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Zhang, Yi-Lin Chiang, Chih-Chao Lee, Yi-Ting Wen, Zhi-Hong Wu, Yang-Chang Wu, Yu-Jen Hwang, Tsong-Long Wu, Tung-Ying Chang, Chia-Yuan Sung, Ping-Jyun Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908) |
| title | Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908) |
| title_full | Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908) |
| title_fullStr | Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908) |
| title_full_unstemmed | Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908) |
| title_short | Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908) |
| title_sort | briarenols q–t: briaranes from a cultured octocoral briareum stechei (kükenthal, 1908) |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460508/ https://www.ncbi.nlm.nih.gov/pubmed/32722176 http://dx.doi.org/10.3390/md18080383 |
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