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The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products

The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due to the significant logistical and operational challenges associated with accessing the deep ocean, bioprospecting programmes that seek to gene...

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Autores principales: Williams, Sam E., Stennett, Henry L., Back, Catherine R., Tiwari, Kavita, Ojeda Gomez, Jorge, Challand, Martin R., Hendry, Katharine R., Spencer, James, Essex-Lopresti, Angela E., Willis, Christine L., Curnow, Paul, Race, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460535/
https://www.ncbi.nlm.nih.gov/pubmed/32823674
http://dx.doi.org/10.3390/antibiotics9080509
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author Williams, Sam E.
Stennett, Henry L.
Back, Catherine R.
Tiwari, Kavita
Ojeda Gomez, Jorge
Challand, Martin R.
Hendry, Katharine R.
Spencer, James
Essex-Lopresti, Angela E.
Willis, Christine L.
Curnow, Paul
Race, Paul R.
author_facet Williams, Sam E.
Stennett, Henry L.
Back, Catherine R.
Tiwari, Kavita
Ojeda Gomez, Jorge
Challand, Martin R.
Hendry, Katharine R.
Spencer, James
Essex-Lopresti, Angela E.
Willis, Christine L.
Curnow, Paul
Race, Paul R.
author_sort Williams, Sam E.
collection PubMed
description The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due to the significant logistical and operational challenges associated with accessing the deep ocean, bioprospecting programmes that seek to generate novel products from marine organisms have, to date, focused predominantly on samples recovered from shallow seas. For this reason, the deep ocean remains a largely untapped resource of novel microbiological life and associated natural products. Here we report the establishment of the Bristol Sponge Microbiome Collection (BISECT), a unique repository of deep-sea microorganisms and associated metabolites isolated from the microbiota of marine sponges, recovered from previously unsurveyed regions of the mid Atlantic Ocean, at depths of 0.3–3 km. An integrated biodiscovery pipeline comprising molecular, genetic, bioinformatic and analytical tools is also described, which is being applied to interrogate this collection. The potential of this approach is illustrated using data reporting our initial efforts to identify antimicrobial natural product lead compounds. Prospects for the use of BISECT to address allied pharmaceutical needs, along with mechanisms of access to the collection are also discussed
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spelling pubmed-74605352020-09-03 The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products Williams, Sam E. Stennett, Henry L. Back, Catherine R. Tiwari, Kavita Ojeda Gomez, Jorge Challand, Martin R. Hendry, Katharine R. Spencer, James Essex-Lopresti, Angela E. Willis, Christine L. Curnow, Paul Race, Paul R. Antibiotics (Basel) Article The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due to the significant logistical and operational challenges associated with accessing the deep ocean, bioprospecting programmes that seek to generate novel products from marine organisms have, to date, focused predominantly on samples recovered from shallow seas. For this reason, the deep ocean remains a largely untapped resource of novel microbiological life and associated natural products. Here we report the establishment of the Bristol Sponge Microbiome Collection (BISECT), a unique repository of deep-sea microorganisms and associated metabolites isolated from the microbiota of marine sponges, recovered from previously unsurveyed regions of the mid Atlantic Ocean, at depths of 0.3–3 km. An integrated biodiscovery pipeline comprising molecular, genetic, bioinformatic and analytical tools is also described, which is being applied to interrogate this collection. The potential of this approach is illustrated using data reporting our initial efforts to identify antimicrobial natural product lead compounds. Prospects for the use of BISECT to address allied pharmaceutical needs, along with mechanisms of access to the collection are also discussed MDPI 2020-08-13 /pmc/articles/PMC7460535/ /pubmed/32823674 http://dx.doi.org/10.3390/antibiotics9080509 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Williams, Sam E.
Stennett, Henry L.
Back, Catherine R.
Tiwari, Kavita
Ojeda Gomez, Jorge
Challand, Martin R.
Hendry, Katharine R.
Spencer, James
Essex-Lopresti, Angela E.
Willis, Christine L.
Curnow, Paul
Race, Paul R.
The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products
title The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products
title_full The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products
title_fullStr The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products
title_full_unstemmed The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products
title_short The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products
title_sort bristol sponge microbiome collection: a unique repository of deep-sea microorganisms and associated natural products
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460535/
https://www.ncbi.nlm.nih.gov/pubmed/32823674
http://dx.doi.org/10.3390/antibiotics9080509
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