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The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products
The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due to the significant logistical and operational challenges associated with accessing the deep ocean, bioprospecting programmes that seek to gene...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460535/ https://www.ncbi.nlm.nih.gov/pubmed/32823674 http://dx.doi.org/10.3390/antibiotics9080509 |
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author | Williams, Sam E. Stennett, Henry L. Back, Catherine R. Tiwari, Kavita Ojeda Gomez, Jorge Challand, Martin R. Hendry, Katharine R. Spencer, James Essex-Lopresti, Angela E. Willis, Christine L. Curnow, Paul Race, Paul R. |
author_facet | Williams, Sam E. Stennett, Henry L. Back, Catherine R. Tiwari, Kavita Ojeda Gomez, Jorge Challand, Martin R. Hendry, Katharine R. Spencer, James Essex-Lopresti, Angela E. Willis, Christine L. Curnow, Paul Race, Paul R. |
author_sort | Williams, Sam E. |
collection | PubMed |
description | The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due to the significant logistical and operational challenges associated with accessing the deep ocean, bioprospecting programmes that seek to generate novel products from marine organisms have, to date, focused predominantly on samples recovered from shallow seas. For this reason, the deep ocean remains a largely untapped resource of novel microbiological life and associated natural products. Here we report the establishment of the Bristol Sponge Microbiome Collection (BISECT), a unique repository of deep-sea microorganisms and associated metabolites isolated from the microbiota of marine sponges, recovered from previously unsurveyed regions of the mid Atlantic Ocean, at depths of 0.3–3 km. An integrated biodiscovery pipeline comprising molecular, genetic, bioinformatic and analytical tools is also described, which is being applied to interrogate this collection. The potential of this approach is illustrated using data reporting our initial efforts to identify antimicrobial natural product lead compounds. Prospects for the use of BISECT to address allied pharmaceutical needs, along with mechanisms of access to the collection are also discussed |
format | Online Article Text |
id | pubmed-7460535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74605352020-09-03 The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products Williams, Sam E. Stennett, Henry L. Back, Catherine R. Tiwari, Kavita Ojeda Gomez, Jorge Challand, Martin R. Hendry, Katharine R. Spencer, James Essex-Lopresti, Angela E. Willis, Christine L. Curnow, Paul Race, Paul R. Antibiotics (Basel) Article The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due to the significant logistical and operational challenges associated with accessing the deep ocean, bioprospecting programmes that seek to generate novel products from marine organisms have, to date, focused predominantly on samples recovered from shallow seas. For this reason, the deep ocean remains a largely untapped resource of novel microbiological life and associated natural products. Here we report the establishment of the Bristol Sponge Microbiome Collection (BISECT), a unique repository of deep-sea microorganisms and associated metabolites isolated from the microbiota of marine sponges, recovered from previously unsurveyed regions of the mid Atlantic Ocean, at depths of 0.3–3 km. An integrated biodiscovery pipeline comprising molecular, genetic, bioinformatic and analytical tools is also described, which is being applied to interrogate this collection. The potential of this approach is illustrated using data reporting our initial efforts to identify antimicrobial natural product lead compounds. Prospects for the use of BISECT to address allied pharmaceutical needs, along with mechanisms of access to the collection are also discussed MDPI 2020-08-13 /pmc/articles/PMC7460535/ /pubmed/32823674 http://dx.doi.org/10.3390/antibiotics9080509 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Williams, Sam E. Stennett, Henry L. Back, Catherine R. Tiwari, Kavita Ojeda Gomez, Jorge Challand, Martin R. Hendry, Katharine R. Spencer, James Essex-Lopresti, Angela E. Willis, Christine L. Curnow, Paul Race, Paul R. The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products |
title | The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products |
title_full | The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products |
title_fullStr | The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products |
title_full_unstemmed | The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products |
title_short | The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products |
title_sort | bristol sponge microbiome collection: a unique repository of deep-sea microorganisms and associated natural products |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460535/ https://www.ncbi.nlm.nih.gov/pubmed/32823674 http://dx.doi.org/10.3390/antibiotics9080509 |
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