Prenylated Flavonoids from the Roots of Tephrosia rhodesica

[Image: see text] Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH(2)Cl(2)–CH(3)OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectros...

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Detalles Bibliográficos
Autores principales: Atilaw, Yoseph, Muiva-Mutisya, Lois, Bogaerts, Jonathan, Duffy, Sandra, Valkonen, Arto, Heydenreich, Matthias, Avery, Vicky M., Rissanen, Kari, Erdélyi, Máté, Yenesew, Abiy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460544/
https://www.ncbi.nlm.nih.gov/pubmed/32790306
http://dx.doi.org/10.1021/acs.jnatprod.0c00245
Descripción
Sumario:[Image: see text] Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH(2)Cl(2)–CH(3)OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC(50) = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.

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