Cargando…
Prenylated Flavonoids from the Roots of Tephrosia rhodesica
[Image: see text] Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH(2)Cl(2)–CH(3)OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectros...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society and American
Society of Pharmacognosy
2020
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460544/ https://www.ncbi.nlm.nih.gov/pubmed/32790306 http://dx.doi.org/10.1021/acs.jnatprod.0c00245 |
| _version_ | 1783576626586451968 |
|---|---|
| author | Atilaw, Yoseph Muiva-Mutisya, Lois Bogaerts, Jonathan Duffy, Sandra Valkonen, Arto Heydenreich, Matthias Avery, Vicky M. Rissanen, Kari Erdélyi, Máté Yenesew, Abiy |
| author_facet | Atilaw, Yoseph Muiva-Mutisya, Lois Bogaerts, Jonathan Duffy, Sandra Valkonen, Arto Heydenreich, Matthias Avery, Vicky M. Rissanen, Kari Erdélyi, Máté Yenesew, Abiy |
| author_sort | Atilaw, Yoseph |
| collection | PubMed |
| description | [Image: see text] Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH(2)Cl(2)–CH(3)OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC(50) = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum. |
| format | Online Article Text |
| id | pubmed-7460544 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American Chemical
Society and American
Society of Pharmacognosy |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74605442020-09-02 Prenylated Flavonoids from the Roots of Tephrosia rhodesica Atilaw, Yoseph Muiva-Mutisya, Lois Bogaerts, Jonathan Duffy, Sandra Valkonen, Arto Heydenreich, Matthias Avery, Vicky M. Rissanen, Kari Erdélyi, Máté Yenesew, Abiy J Nat Prod [Image: see text] Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH(2)Cl(2)–CH(3)OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC(50) = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum. American Chemical Society and American Society of Pharmacognosy 2020-08-13 2020-08-28 /pmc/articles/PMC7460544/ /pubmed/32790306 http://dx.doi.org/10.1021/acs.jnatprod.0c00245 Text en Copyright © 2020 American Chemical Society and American Society of Pharmacognosy This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
| spellingShingle | Atilaw, Yoseph Muiva-Mutisya, Lois Bogaerts, Jonathan Duffy, Sandra Valkonen, Arto Heydenreich, Matthias Avery, Vicky M. Rissanen, Kari Erdélyi, Máté Yenesew, Abiy Prenylated Flavonoids from the Roots of Tephrosia rhodesica |
| title | Prenylated Flavonoids from the Roots of Tephrosia
rhodesica |
| title_full | Prenylated Flavonoids from the Roots of Tephrosia
rhodesica |
| title_fullStr | Prenylated Flavonoids from the Roots of Tephrosia
rhodesica |
| title_full_unstemmed | Prenylated Flavonoids from the Roots of Tephrosia
rhodesica |
| title_short | Prenylated Flavonoids from the Roots of Tephrosia
rhodesica |
| title_sort | prenylated flavonoids from the roots of tephrosia
rhodesica |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460544/ https://www.ncbi.nlm.nih.gov/pubmed/32790306 http://dx.doi.org/10.1021/acs.jnatprod.0c00245 |
| work_keys_str_mv | AT atilawyoseph prenylatedflavonoidsfromtherootsoftephrosiarhodesica AT muivamutisyalois prenylatedflavonoidsfromtherootsoftephrosiarhodesica AT bogaertsjonathan prenylatedflavonoidsfromtherootsoftephrosiarhodesica AT duffysandra prenylatedflavonoidsfromtherootsoftephrosiarhodesica AT valkonenarto prenylatedflavonoidsfromtherootsoftephrosiarhodesica AT heydenreichmatthias prenylatedflavonoidsfromtherootsoftephrosiarhodesica AT averyvickym prenylatedflavonoidsfromtherootsoftephrosiarhodesica AT rissanenkari prenylatedflavonoidsfromtherootsoftephrosiarhodesica AT erdelyimate prenylatedflavonoidsfromtherootsoftephrosiarhodesica AT yenesewabiy prenylatedflavonoidsfromtherootsoftephrosiarhodesica |