Recent Progress on Relevant microRNAs in Autism Spectrum Disorders

Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-tra...

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Detalles Bibliográficos
Autores principales: Wu, Xingwang, Li, Wanran, Zheng, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460584/
https://www.ncbi.nlm.nih.gov/pubmed/32824515
http://dx.doi.org/10.3390/ijms21165904
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author Wu, Xingwang
Li, Wanran
Zheng, Yun
author_facet Wu, Xingwang
Li, Wanran
Zheng, Yun
author_sort Wu, Xingwang
collection PubMed
description Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases. In this review, we summarize relevant miRNAs in ASD, and analyze dysregulated miRNAs in brain tissues and body fluids of ASD patients, which may contribute to the pathogenesis and diagnosis of ASD.
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spelling pubmed-74605842020-09-03 Recent Progress on Relevant microRNAs in Autism Spectrum Disorders Wu, Xingwang Li, Wanran Zheng, Yun Int J Mol Sci Review Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases. In this review, we summarize relevant miRNAs in ASD, and analyze dysregulated miRNAs in brain tissues and body fluids of ASD patients, which may contribute to the pathogenesis and diagnosis of ASD. MDPI 2020-08-17 /pmc/articles/PMC7460584/ /pubmed/32824515 http://dx.doi.org/10.3390/ijms21165904 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Xingwang
Li, Wanran
Zheng, Yun
Recent Progress on Relevant microRNAs in Autism Spectrum Disorders
title Recent Progress on Relevant microRNAs in Autism Spectrum Disorders
title_full Recent Progress on Relevant microRNAs in Autism Spectrum Disorders
title_fullStr Recent Progress on Relevant microRNAs in Autism Spectrum Disorders
title_full_unstemmed Recent Progress on Relevant microRNAs in Autism Spectrum Disorders
title_short Recent Progress on Relevant microRNAs in Autism Spectrum Disorders
title_sort recent progress on relevant micrornas in autism spectrum disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460584/
https://www.ncbi.nlm.nih.gov/pubmed/32824515
http://dx.doi.org/10.3390/ijms21165904
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