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Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms

Neurogenesis is the process by which functional new neurons are generated from the neural stem cells (NSCs) or neural progenitor cells (NPCs). Increasing lines of evidence show that neurogenesis impairment is involved in different neurological illnesses, including mood disorders, neurogenerative dis...

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Autores principales: Leung, Joseph Wai-Hin, Cheung, Kwok-Kuen, Ngai, Shirley Pui-Ching, Tsang, Hector Wing-Hong, Lau, Benson Wui-Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460604/
https://www.ncbi.nlm.nih.gov/pubmed/32781737
http://dx.doi.org/10.3390/ijms21165645
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author Leung, Joseph Wai-Hin
Cheung, Kwok-Kuen
Ngai, Shirley Pui-Ching
Tsang, Hector Wing-Hong
Lau, Benson Wui-Man
author_facet Leung, Joseph Wai-Hin
Cheung, Kwok-Kuen
Ngai, Shirley Pui-Ching
Tsang, Hector Wing-Hong
Lau, Benson Wui-Man
author_sort Leung, Joseph Wai-Hin
collection PubMed
description Neurogenesis is the process by which functional new neurons are generated from the neural stem cells (NSCs) or neural progenitor cells (NPCs). Increasing lines of evidence show that neurogenesis impairment is involved in different neurological illnesses, including mood disorders, neurogenerative diseases, and central nervous system (CNS) injuries. Since reversing neurogenesis impairment was found to improve neurological outcomes in the pathological conditions, it is speculated that modulating neurogenesis is a potential therapeutic strategy for neurological diseases. Among different modulators of neurogenesis, melatonin is a particularly interesting one. In traditional understanding, melatonin controls the circadian rhythm and sleep–wake cycle, although it is not directly involved in the proliferation and survival of neurons. In the last decade, it was reported that melatonin plays an important role in the regulation of neurogenesis, and thus it may be a potential treatment for neurogenesis-related disorders. The present review aims to summarize and discuss the recent findings regarding the protective effects of melatonin on the neurogenesis impairment in different neurological conditions. We also address the molecular mechanisms involved in the actions of melatonin in neurogenesis modulation.
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spelling pubmed-74606042020-09-03 Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms Leung, Joseph Wai-Hin Cheung, Kwok-Kuen Ngai, Shirley Pui-Ching Tsang, Hector Wing-Hong Lau, Benson Wui-Man Int J Mol Sci Review Neurogenesis is the process by which functional new neurons are generated from the neural stem cells (NSCs) or neural progenitor cells (NPCs). Increasing lines of evidence show that neurogenesis impairment is involved in different neurological illnesses, including mood disorders, neurogenerative diseases, and central nervous system (CNS) injuries. Since reversing neurogenesis impairment was found to improve neurological outcomes in the pathological conditions, it is speculated that modulating neurogenesis is a potential therapeutic strategy for neurological diseases. Among different modulators of neurogenesis, melatonin is a particularly interesting one. In traditional understanding, melatonin controls the circadian rhythm and sleep–wake cycle, although it is not directly involved in the proliferation and survival of neurons. In the last decade, it was reported that melatonin plays an important role in the regulation of neurogenesis, and thus it may be a potential treatment for neurogenesis-related disorders. The present review aims to summarize and discuss the recent findings regarding the protective effects of melatonin on the neurogenesis impairment in different neurological conditions. We also address the molecular mechanisms involved in the actions of melatonin in neurogenesis modulation. MDPI 2020-08-06 /pmc/articles/PMC7460604/ /pubmed/32781737 http://dx.doi.org/10.3390/ijms21165645 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Leung, Joseph Wai-Hin
Cheung, Kwok-Kuen
Ngai, Shirley Pui-Ching
Tsang, Hector Wing-Hong
Lau, Benson Wui-Man
Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms
title Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms
title_full Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms
title_fullStr Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms
title_full_unstemmed Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms
title_short Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms
title_sort protective effects of melatonin on neurogenesis impairment in neurological disorders and its relevant molecular mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460604/
https://www.ncbi.nlm.nih.gov/pubmed/32781737
http://dx.doi.org/10.3390/ijms21165645
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