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Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration

Physical exercise (PE) improves physical performance, mental status, general health, and well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE is beneficial for people suffering from neuro-degenerative diseases because it improves the production of neurotrophic...

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Detalles Bibliográficos
Autores principales: Mahalakshmi, B., Maurya, Nancy, Lee, Shin-Da, Bharath Kumar, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460620/
https://www.ncbi.nlm.nih.gov/pubmed/32824367
http://dx.doi.org/10.3390/ijms21165895
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author Mahalakshmi, B.
Maurya, Nancy
Lee, Shin-Da
Bharath Kumar, V.
author_facet Mahalakshmi, B.
Maurya, Nancy
Lee, Shin-Da
Bharath Kumar, V.
author_sort Mahalakshmi, B.
collection PubMed
description Physical exercise (PE) improves physical performance, mental status, general health, and well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE is beneficial for people suffering from neuro-degenerative diseases because it improves the production of neurotrophic factors, neurotransmitters, and hormones. PE promotes neuronal survival and neuroplasticity and also optimizes neuroendocrine and physiological responses to psychosocial and physical stress. PE sensitizes the parasympathetic nervous system (PNS), Autonomic Nervous System (ANS) and central nervous system (CNS) by promoting many processes such as synaptic plasticity, neurogenesis, angiogenesis, and autophagy. Overall, it carries out many protective and preventive activities such as improvements in memory, cognition, sleep and mood; growth of new blood vessels in nervous system; and the reduction of stress, anxiety, neuro-inflammation, and insulin resistance. In the present work, the protective effects of PE were overviewed. Suitable examples from the current research work in this context are also given in the article.
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spelling pubmed-74606202020-09-03 Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration Mahalakshmi, B. Maurya, Nancy Lee, Shin-Da Bharath Kumar, V. Int J Mol Sci Review Physical exercise (PE) improves physical performance, mental status, general health, and well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE is beneficial for people suffering from neuro-degenerative diseases because it improves the production of neurotrophic factors, neurotransmitters, and hormones. PE promotes neuronal survival and neuroplasticity and also optimizes neuroendocrine and physiological responses to psychosocial and physical stress. PE sensitizes the parasympathetic nervous system (PNS), Autonomic Nervous System (ANS) and central nervous system (CNS) by promoting many processes such as synaptic plasticity, neurogenesis, angiogenesis, and autophagy. Overall, it carries out many protective and preventive activities such as improvements in memory, cognition, sleep and mood; growth of new blood vessels in nervous system; and the reduction of stress, anxiety, neuro-inflammation, and insulin resistance. In the present work, the protective effects of PE were overviewed. Suitable examples from the current research work in this context are also given in the article. MDPI 2020-08-16 /pmc/articles/PMC7460620/ /pubmed/32824367 http://dx.doi.org/10.3390/ijms21165895 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mahalakshmi, B.
Maurya, Nancy
Lee, Shin-Da
Bharath Kumar, V.
Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration
title Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration
title_full Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration
title_fullStr Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration
title_full_unstemmed Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration
title_short Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration
title_sort possible neuroprotective mechanisms of physical exercise in neurodegeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460620/
https://www.ncbi.nlm.nih.gov/pubmed/32824367
http://dx.doi.org/10.3390/ijms21165895
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