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Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance

This review highlights the importance and the complexity of tumour biology and microenvironment in the progression and therapy resistance of glioma. Specific gene mutations, the possible functions of several non-coding microRNAs and the intra-tumour and inter-tumour heterogeneity of cell types contr...

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Autores principales: Valtorta, Silvia, Salvatore, Daniela, Rainone, Paolo, Belloli, Sara, Bertoli, Gloria, Moresco, Rosa Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460665/
https://www.ncbi.nlm.nih.gov/pubmed/32781585
http://dx.doi.org/10.3390/ijms21165631
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author Valtorta, Silvia
Salvatore, Daniela
Rainone, Paolo
Belloli, Sara
Bertoli, Gloria
Moresco, Rosa Maria
author_facet Valtorta, Silvia
Salvatore, Daniela
Rainone, Paolo
Belloli, Sara
Bertoli, Gloria
Moresco, Rosa Maria
author_sort Valtorta, Silvia
collection PubMed
description This review highlights the importance and the complexity of tumour biology and microenvironment in the progression and therapy resistance of glioma. Specific gene mutations, the possible functions of several non-coding microRNAs and the intra-tumour and inter-tumour heterogeneity of cell types contribute to limit the efficacy of the actual therapeutic options. In this scenario, identification of molecular biomarkers of response and the use of multimodal in vivo imaging and in particular the Positron Emission Tomography (PET) based molecular approach, can help identifying glioma features and the modifications occurring during therapy at a regional level. Indeed, a better understanding of tumor heterogeneity and the development of diagnostic procedures can favor the identification of a cluster of patients for personalized medicine in order to improve the survival and their quality of life.
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spelling pubmed-74606652020-09-03 Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance Valtorta, Silvia Salvatore, Daniela Rainone, Paolo Belloli, Sara Bertoli, Gloria Moresco, Rosa Maria Int J Mol Sci Review This review highlights the importance and the complexity of tumour biology and microenvironment in the progression and therapy resistance of glioma. Specific gene mutations, the possible functions of several non-coding microRNAs and the intra-tumour and inter-tumour heterogeneity of cell types contribute to limit the efficacy of the actual therapeutic options. In this scenario, identification of molecular biomarkers of response and the use of multimodal in vivo imaging and in particular the Positron Emission Tomography (PET) based molecular approach, can help identifying glioma features and the modifications occurring during therapy at a regional level. Indeed, a better understanding of tumor heterogeneity and the development of diagnostic procedures can favor the identification of a cluster of patients for personalized medicine in order to improve the survival and their quality of life. MDPI 2020-08-06 /pmc/articles/PMC7460665/ /pubmed/32781585 http://dx.doi.org/10.3390/ijms21165631 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Valtorta, Silvia
Salvatore, Daniela
Rainone, Paolo
Belloli, Sara
Bertoli, Gloria
Moresco, Rosa Maria
Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance
title Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance
title_full Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance
title_fullStr Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance
title_full_unstemmed Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance
title_short Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance
title_sort molecular and cellular complexity of glioma. focus on tumour microenvironment and the use of molecular and imaging biomarkers to overcome treatment resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460665/
https://www.ncbi.nlm.nih.gov/pubmed/32781585
http://dx.doi.org/10.3390/ijms21165631
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