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Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance
This review highlights the importance and the complexity of tumour biology and microenvironment in the progression and therapy resistance of glioma. Specific gene mutations, the possible functions of several non-coding microRNAs and the intra-tumour and inter-tumour heterogeneity of cell types contr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460665/ https://www.ncbi.nlm.nih.gov/pubmed/32781585 http://dx.doi.org/10.3390/ijms21165631 |
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author | Valtorta, Silvia Salvatore, Daniela Rainone, Paolo Belloli, Sara Bertoli, Gloria Moresco, Rosa Maria |
author_facet | Valtorta, Silvia Salvatore, Daniela Rainone, Paolo Belloli, Sara Bertoli, Gloria Moresco, Rosa Maria |
author_sort | Valtorta, Silvia |
collection | PubMed |
description | This review highlights the importance and the complexity of tumour biology and microenvironment in the progression and therapy resistance of glioma. Specific gene mutations, the possible functions of several non-coding microRNAs and the intra-tumour and inter-tumour heterogeneity of cell types contribute to limit the efficacy of the actual therapeutic options. In this scenario, identification of molecular biomarkers of response and the use of multimodal in vivo imaging and in particular the Positron Emission Tomography (PET) based molecular approach, can help identifying glioma features and the modifications occurring during therapy at a regional level. Indeed, a better understanding of tumor heterogeneity and the development of diagnostic procedures can favor the identification of a cluster of patients for personalized medicine in order to improve the survival and their quality of life. |
format | Online Article Text |
id | pubmed-7460665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74606652020-09-03 Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance Valtorta, Silvia Salvatore, Daniela Rainone, Paolo Belloli, Sara Bertoli, Gloria Moresco, Rosa Maria Int J Mol Sci Review This review highlights the importance and the complexity of tumour biology and microenvironment in the progression and therapy resistance of glioma. Specific gene mutations, the possible functions of several non-coding microRNAs and the intra-tumour and inter-tumour heterogeneity of cell types contribute to limit the efficacy of the actual therapeutic options. In this scenario, identification of molecular biomarkers of response and the use of multimodal in vivo imaging and in particular the Positron Emission Tomography (PET) based molecular approach, can help identifying glioma features and the modifications occurring during therapy at a regional level. Indeed, a better understanding of tumor heterogeneity and the development of diagnostic procedures can favor the identification of a cluster of patients for personalized medicine in order to improve the survival and their quality of life. MDPI 2020-08-06 /pmc/articles/PMC7460665/ /pubmed/32781585 http://dx.doi.org/10.3390/ijms21165631 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Valtorta, Silvia Salvatore, Daniela Rainone, Paolo Belloli, Sara Bertoli, Gloria Moresco, Rosa Maria Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance |
title | Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance |
title_full | Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance |
title_fullStr | Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance |
title_full_unstemmed | Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance |
title_short | Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance |
title_sort | molecular and cellular complexity of glioma. focus on tumour microenvironment and the use of molecular and imaging biomarkers to overcome treatment resistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460665/ https://www.ncbi.nlm.nih.gov/pubmed/32781585 http://dx.doi.org/10.3390/ijms21165631 |
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