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Usefulness of Kawasaki disease risk scoring systems to the Turkish population

OBJECTIVE: Kawasaki disease (KD) is the most common cause of coronary artery aneurysm (CAA) in children. The available risk scores to predict intravenous immunoglobulin (IVIG) resistance and CAA were developed in Asian populations in whom their effectiveness has been proven, but data on non-Asian ch...

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Autores principales: Öztarhan, Kazım, Varlı, Yusuf Ziya, Ayaz, Nuray Aktay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460684/
https://www.ncbi.nlm.nih.gov/pubmed/32749248
http://dx.doi.org/10.14744/AnatolJCardiol.2020.37560
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author Öztarhan, Kazım
Varlı, Yusuf Ziya
Ayaz, Nuray Aktay
author_facet Öztarhan, Kazım
Varlı, Yusuf Ziya
Ayaz, Nuray Aktay
author_sort Öztarhan, Kazım
collection PubMed
description OBJECTIVE: Kawasaki disease (KD) is the most common cause of coronary artery aneurysm (CAA) in children. The available risk scores to predict intravenous immunoglobulin (IVIG) resistance and CAA were developed in Asian populations in whom their effectiveness has been proven, but data on non-Asian children are limited. This study aimed to evaluate the ability of 5 risk scoring systems to predict IVIG resistance and CAA in Turkey patients with KD. METHODS: Patients with KD were retrospectively evaluated with clinical, laboratory, and echocardiographic findings. Data analyses were performed in 5 scoring systems (Harada, Kobayashi, Egami, Formosa, and Sano). RESULTS: A total of 259 patients (Male: Female, 1.7) were treated for KD in our hospital. The mean age of diagnosis in patients with KD, CAA, and IVIG resistance were 3.31, 2.19, and 2.06, respectively. CAA development and IVIG resistance were seen in 11.6% and 12.3% of cases, respectively. IVIG resistance was detected in 35.6% of patients with CAA. In our study, 5 risk scoring systems were applied to our patients. ROC analysis results were found highest in Kobayashi scoring system for IVIG resistance (AUC, 0.864) and in Harada scoring system for CAA development (AUC, 0.727). CONCLUSION: Harada score was significant in predicting CAA risk, and Kobayashi score was significant in predicting the risk of developing IVIG resistance. It is necessary to determine more specific and sensitive risk scores that increase the risk of IVIG resistance and the development of CAA in Turkey.
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spelling pubmed-74606842020-09-16 Usefulness of Kawasaki disease risk scoring systems to the Turkish population Öztarhan, Kazım Varlı, Yusuf Ziya Ayaz, Nuray Aktay Anatol J Cardiol Original Investigation OBJECTIVE: Kawasaki disease (KD) is the most common cause of coronary artery aneurysm (CAA) in children. The available risk scores to predict intravenous immunoglobulin (IVIG) resistance and CAA were developed in Asian populations in whom their effectiveness has been proven, but data on non-Asian children are limited. This study aimed to evaluate the ability of 5 risk scoring systems to predict IVIG resistance and CAA in Turkey patients with KD. METHODS: Patients with KD were retrospectively evaluated with clinical, laboratory, and echocardiographic findings. Data analyses were performed in 5 scoring systems (Harada, Kobayashi, Egami, Formosa, and Sano). RESULTS: A total of 259 patients (Male: Female, 1.7) were treated for KD in our hospital. The mean age of diagnosis in patients with KD, CAA, and IVIG resistance were 3.31, 2.19, and 2.06, respectively. CAA development and IVIG resistance were seen in 11.6% and 12.3% of cases, respectively. IVIG resistance was detected in 35.6% of patients with CAA. In our study, 5 risk scoring systems were applied to our patients. ROC analysis results were found highest in Kobayashi scoring system for IVIG resistance (AUC, 0.864) and in Harada scoring system for CAA development (AUC, 0.727). CONCLUSION: Harada score was significant in predicting CAA risk, and Kobayashi score was significant in predicting the risk of developing IVIG resistance. It is necessary to determine more specific and sensitive risk scores that increase the risk of IVIG resistance and the development of CAA in Turkey. Kare Publishing 2020-08 2020-07-28 /pmc/articles/PMC7460684/ /pubmed/32749248 http://dx.doi.org/10.14744/AnatolJCardiol.2020.37560 Text en Copyright: © 2020 Turkish Society of Cardiology http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Investigation
Öztarhan, Kazım
Varlı, Yusuf Ziya
Ayaz, Nuray Aktay
Usefulness of Kawasaki disease risk scoring systems to the Turkish population
title Usefulness of Kawasaki disease risk scoring systems to the Turkish population
title_full Usefulness of Kawasaki disease risk scoring systems to the Turkish population
title_fullStr Usefulness of Kawasaki disease risk scoring systems to the Turkish population
title_full_unstemmed Usefulness of Kawasaki disease risk scoring systems to the Turkish population
title_short Usefulness of Kawasaki disease risk scoring systems to the Turkish population
title_sort usefulness of kawasaki disease risk scoring systems to the turkish population
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460684/
https://www.ncbi.nlm.nih.gov/pubmed/32749248
http://dx.doi.org/10.14744/AnatolJCardiol.2020.37560
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