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Matrix Metalloproteinases in Age-Related Macular Degeneration (AMD)

Age-related macular degeneration (AMD) is a complex, multifactorial and progressive retinal disease affecting millions of people worldwide. In developed countries, it is the leading cause of vision loss and legal blindness among the elderly. Although the pathogenesis of AMD is still barely understoo...

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Autores principales: García-Onrubia, Luis, Valentín-Bravo, Fco. Javier, Coco-Martin, Rosa M., González-Sarmiento, Rogelio, Pastor, J. Carlos, Usategui-Martín, Ricardo, Pastor-Idoate, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460693/
https://www.ncbi.nlm.nih.gov/pubmed/32824762
http://dx.doi.org/10.3390/ijms21165934
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author García-Onrubia, Luis
Valentín-Bravo, Fco. Javier
Coco-Martin, Rosa M.
González-Sarmiento, Rogelio
Pastor, J. Carlos
Usategui-Martín, Ricardo
Pastor-Idoate, Salvador
author_facet García-Onrubia, Luis
Valentín-Bravo, Fco. Javier
Coco-Martin, Rosa M.
González-Sarmiento, Rogelio
Pastor, J. Carlos
Usategui-Martín, Ricardo
Pastor-Idoate, Salvador
author_sort García-Onrubia, Luis
collection PubMed
description Age-related macular degeneration (AMD) is a complex, multifactorial and progressive retinal disease affecting millions of people worldwide. In developed countries, it is the leading cause of vision loss and legal blindness among the elderly. Although the pathogenesis of AMD is still barely understood, recent studies have reported that disorders in the regulation of the extracellular matrix (ECM) play an important role in its etiopathogenesis. The dynamic metabolism of the ECM is closely regulated by matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs). The present review focuses on the crucial processes that occur at the level of the Bruch’s membrane, with special emphasis on MMPs, TIMPs, and the polymorphisms associated with increased susceptibility to AMD development. A systematic literature search was performed, covering the years 1990–2020, using the following keywords: AMD, extracellular matrix, Bruch’s membrane, MMPs, TIMPs, and MMPs polymorphisms in AMD. In both early and advanced AMD, the pathological dynamic changes of ECM structural components are caused by the dysfunction of specific regulators and by the influence of other regulatory systems connected with both genetic and environmental factors. Better insight into the pathological role of MMP/TIMP complexes may lead to the development of new strategies for AMD treatment and prevention.
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spelling pubmed-74606932020-09-03 Matrix Metalloproteinases in Age-Related Macular Degeneration (AMD) García-Onrubia, Luis Valentín-Bravo, Fco. Javier Coco-Martin, Rosa M. González-Sarmiento, Rogelio Pastor, J. Carlos Usategui-Martín, Ricardo Pastor-Idoate, Salvador Int J Mol Sci Review Age-related macular degeneration (AMD) is a complex, multifactorial and progressive retinal disease affecting millions of people worldwide. In developed countries, it is the leading cause of vision loss and legal blindness among the elderly. Although the pathogenesis of AMD is still barely understood, recent studies have reported that disorders in the regulation of the extracellular matrix (ECM) play an important role in its etiopathogenesis. The dynamic metabolism of the ECM is closely regulated by matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs). The present review focuses on the crucial processes that occur at the level of the Bruch’s membrane, with special emphasis on MMPs, TIMPs, and the polymorphisms associated with increased susceptibility to AMD development. A systematic literature search was performed, covering the years 1990–2020, using the following keywords: AMD, extracellular matrix, Bruch’s membrane, MMPs, TIMPs, and MMPs polymorphisms in AMD. In both early and advanced AMD, the pathological dynamic changes of ECM structural components are caused by the dysfunction of specific regulators and by the influence of other regulatory systems connected with both genetic and environmental factors. Better insight into the pathological role of MMP/TIMP complexes may lead to the development of new strategies for AMD treatment and prevention. MDPI 2020-08-18 /pmc/articles/PMC7460693/ /pubmed/32824762 http://dx.doi.org/10.3390/ijms21165934 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
García-Onrubia, Luis
Valentín-Bravo, Fco. Javier
Coco-Martin, Rosa M.
González-Sarmiento, Rogelio
Pastor, J. Carlos
Usategui-Martín, Ricardo
Pastor-Idoate, Salvador
Matrix Metalloproteinases in Age-Related Macular Degeneration (AMD)
title Matrix Metalloproteinases in Age-Related Macular Degeneration (AMD)
title_full Matrix Metalloproteinases in Age-Related Macular Degeneration (AMD)
title_fullStr Matrix Metalloproteinases in Age-Related Macular Degeneration (AMD)
title_full_unstemmed Matrix Metalloproteinases in Age-Related Macular Degeneration (AMD)
title_short Matrix Metalloproteinases in Age-Related Macular Degeneration (AMD)
title_sort matrix metalloproteinases in age-related macular degeneration (amd)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460693/
https://www.ncbi.nlm.nih.gov/pubmed/32824762
http://dx.doi.org/10.3390/ijms21165934
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