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The human microbiome and its link in prostate cancer risk and pathogenesis
There is growing evidence of the microbiome’s role in human health and disease since the human microbiome project. The microbiome plays a vital role in influencing cancer risk and pathogenesis. Several studies indicate microbial pathogens to account for over 15–20% of all cancers. Furthermore, the i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460756/ https://www.ncbi.nlm.nih.gov/pubmed/32884579 http://dx.doi.org/10.1186/s13027-020-00319-2 |
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author | Katongole, Paul Sande, Obondo J. Joloba, Moses Reynolds, Steven J. Niyonzima, Nixon |
author_facet | Katongole, Paul Sande, Obondo J. Joloba, Moses Reynolds, Steven J. Niyonzima, Nixon |
author_sort | Katongole, Paul |
collection | PubMed |
description | There is growing evidence of the microbiome’s role in human health and disease since the human microbiome project. The microbiome plays a vital role in influencing cancer risk and pathogenesis. Several studies indicate microbial pathogens to account for over 15–20% of all cancers. Furthermore, the interaction of the microbiota, especially the gut microbiota in influencing response to chemotherapy, immunotherapy, and radiotherapy remains an area of active research. Certain microbial species have been linked to the improved clinical outcome when on different cancer therapies. The recent discovery of the urinary microbiome has enabled the study to understand its connection to genitourinary malignancies, especially prostate cancer. Prostate cancer is the second most common cancer in males worldwide. Therefore research into understanding the factors and mechanisms associated with prostate cancer etiology, pathogenesis, and disease progression is of utmost importance. In this review, we explore the current literature concerning the link between the gut and urinary microbiome and prostate cancer risk and pathogenesis. |
format | Online Article Text |
id | pubmed-7460756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74607562020-09-02 The human microbiome and its link in prostate cancer risk and pathogenesis Katongole, Paul Sande, Obondo J. Joloba, Moses Reynolds, Steven J. Niyonzima, Nixon Infect Agent Cancer Review There is growing evidence of the microbiome’s role in human health and disease since the human microbiome project. The microbiome plays a vital role in influencing cancer risk and pathogenesis. Several studies indicate microbial pathogens to account for over 15–20% of all cancers. Furthermore, the interaction of the microbiota, especially the gut microbiota in influencing response to chemotherapy, immunotherapy, and radiotherapy remains an area of active research. Certain microbial species have been linked to the improved clinical outcome when on different cancer therapies. The recent discovery of the urinary microbiome has enabled the study to understand its connection to genitourinary malignancies, especially prostate cancer. Prostate cancer is the second most common cancer in males worldwide. Therefore research into understanding the factors and mechanisms associated with prostate cancer etiology, pathogenesis, and disease progression is of utmost importance. In this review, we explore the current literature concerning the link between the gut and urinary microbiome and prostate cancer risk and pathogenesis. BioMed Central 2020-08-31 /pmc/articles/PMC7460756/ /pubmed/32884579 http://dx.doi.org/10.1186/s13027-020-00319-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Katongole, Paul Sande, Obondo J. Joloba, Moses Reynolds, Steven J. Niyonzima, Nixon The human microbiome and its link in prostate cancer risk and pathogenesis |
title | The human microbiome and its link in prostate cancer risk and pathogenesis |
title_full | The human microbiome and its link in prostate cancer risk and pathogenesis |
title_fullStr | The human microbiome and its link in prostate cancer risk and pathogenesis |
title_full_unstemmed | The human microbiome and its link in prostate cancer risk and pathogenesis |
title_short | The human microbiome and its link in prostate cancer risk and pathogenesis |
title_sort | human microbiome and its link in prostate cancer risk and pathogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460756/ https://www.ncbi.nlm.nih.gov/pubmed/32884579 http://dx.doi.org/10.1186/s13027-020-00319-2 |
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