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Microbiota-Derived Metabolites in Tumor Progression and Metastasis

Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic relationship that contributes to the maintenance of cellular metabolism and of the immune and neuronal systems. This dialogue normally occurs through the production and regulation of hormonal intermediates, me...

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Autores principales: Rossi, Tania, Vergara, Daniele, Fanini, Francesca, Maffia, Michele, Bravaccini, Sara, Pirini, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460823/
https://www.ncbi.nlm.nih.gov/pubmed/32806665
http://dx.doi.org/10.3390/ijms21165786
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author Rossi, Tania
Vergara, Daniele
Fanini, Francesca
Maffia, Michele
Bravaccini, Sara
Pirini, Francesca
author_facet Rossi, Tania
Vergara, Daniele
Fanini, Francesca
Maffia, Michele
Bravaccini, Sara
Pirini, Francesca
author_sort Rossi, Tania
collection PubMed
description Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic relationship that contributes to the maintenance of cellular metabolism and of the immune and neuronal systems. This dialogue normally occurs through the production and regulation of hormonal intermediates, metabolites, secondary metabolites, proteins, and toxins. When the balance between host and microbiota is compromised, the dynamics of this relationship change, creating favorable conditions for the development of diseases, including cancers. Microbiome metabolites can be important modulators of the tumor microenvironment contributing to regulate inflammation, proliferation, and cell death, in either a positive or negative way. Recent studies also highlight the involvement of microbiota metabolites in inducing epithelial–mesenchymal transition, thus favoring the setup of the metastatic niche. An investigation of microbe-derived metabolites in “liquid” human samples, such as plasma, serum, and urine, provide further information to clarify the relationship between host and microbiota.
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spelling pubmed-74608232020-09-03 Microbiota-Derived Metabolites in Tumor Progression and Metastasis Rossi, Tania Vergara, Daniele Fanini, Francesca Maffia, Michele Bravaccini, Sara Pirini, Francesca Int J Mol Sci Review Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic relationship that contributes to the maintenance of cellular metabolism and of the immune and neuronal systems. This dialogue normally occurs through the production and regulation of hormonal intermediates, metabolites, secondary metabolites, proteins, and toxins. When the balance between host and microbiota is compromised, the dynamics of this relationship change, creating favorable conditions for the development of diseases, including cancers. Microbiome metabolites can be important modulators of the tumor microenvironment contributing to regulate inflammation, proliferation, and cell death, in either a positive or negative way. Recent studies also highlight the involvement of microbiota metabolites in inducing epithelial–mesenchymal transition, thus favoring the setup of the metastatic niche. An investigation of microbe-derived metabolites in “liquid” human samples, such as plasma, serum, and urine, provide further information to clarify the relationship between host and microbiota. MDPI 2020-08-12 /pmc/articles/PMC7460823/ /pubmed/32806665 http://dx.doi.org/10.3390/ijms21165786 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rossi, Tania
Vergara, Daniele
Fanini, Francesca
Maffia, Michele
Bravaccini, Sara
Pirini, Francesca
Microbiota-Derived Metabolites in Tumor Progression and Metastasis
title Microbiota-Derived Metabolites in Tumor Progression and Metastasis
title_full Microbiota-Derived Metabolites in Tumor Progression and Metastasis
title_fullStr Microbiota-Derived Metabolites in Tumor Progression and Metastasis
title_full_unstemmed Microbiota-Derived Metabolites in Tumor Progression and Metastasis
title_short Microbiota-Derived Metabolites in Tumor Progression and Metastasis
title_sort microbiota-derived metabolites in tumor progression and metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460823/
https://www.ncbi.nlm.nih.gov/pubmed/32806665
http://dx.doi.org/10.3390/ijms21165786
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