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Alzheimer’s Disease Mouse as a Model of Testis Degeneration

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with protective functions in the central nervous system and various peripheral organs. PACAP has the highest expression level in the testes, among the peripheral organs, and has a positive regulative role in spermatogenesis...

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Autores principales: Szegeczki, Vince, Horváth, Gabriella, Perényi, Helga, Tamás, Andrea, Radák, Zsolt, Ábrahám, Dóra, Zákány, Róza, Reglodi, Dora, Juhász, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460847/
https://www.ncbi.nlm.nih.gov/pubmed/32785075
http://dx.doi.org/10.3390/ijms21165726
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author Szegeczki, Vince
Horváth, Gabriella
Perényi, Helga
Tamás, Andrea
Radák, Zsolt
Ábrahám, Dóra
Zákány, Róza
Reglodi, Dora
Juhász, Tamás
author_facet Szegeczki, Vince
Horváth, Gabriella
Perényi, Helga
Tamás, Andrea
Radák, Zsolt
Ábrahám, Dóra
Zákány, Róza
Reglodi, Dora
Juhász, Tamás
author_sort Szegeczki, Vince
collection PubMed
description Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with protective functions in the central nervous system and various peripheral organs. PACAP has the highest expression level in the testes, among the peripheral organs, and has a positive regulative role in spermatogenesis and in sperm motility. In the present study, we explored testicular degenerative alterations in a mouse model of Alzheimer’s disease (AD) (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) and demonstrated changes in PACAP-regulated signaling pathways. In addition, the effects of increased physical activity of AD (trained AD (TAD)) mice on testis were also followed. Reduced cell number and decreased thickness of basement membrane were detected in AD samples. These changes were compensated by physical activity. Expression of PACAP receptors and canonical signaling elements such as PKA, P-PKA, PP2A significantly decreased in AD mice, and altered Sox transcription factor expression was also detected. Via this signaling mechanism, physical activity compensated the negative effects of AD on the expression of type IV collagen. Our findings suggest that the testes of AD mice can be a good model of testis degeneration. Moreover, it can be an appropriate organ to follow the effects of various interventions such as physical activity on tissue regeneration and signaling alterations.
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spelling pubmed-74608472020-09-14 Alzheimer’s Disease Mouse as a Model of Testis Degeneration Szegeczki, Vince Horváth, Gabriella Perényi, Helga Tamás, Andrea Radák, Zsolt Ábrahám, Dóra Zákány, Róza Reglodi, Dora Juhász, Tamás Int J Mol Sci Article Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with protective functions in the central nervous system and various peripheral organs. PACAP has the highest expression level in the testes, among the peripheral organs, and has a positive regulative role in spermatogenesis and in sperm motility. In the present study, we explored testicular degenerative alterations in a mouse model of Alzheimer’s disease (AD) (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) and demonstrated changes in PACAP-regulated signaling pathways. In addition, the effects of increased physical activity of AD (trained AD (TAD)) mice on testis were also followed. Reduced cell number and decreased thickness of basement membrane were detected in AD samples. These changes were compensated by physical activity. Expression of PACAP receptors and canonical signaling elements such as PKA, P-PKA, PP2A significantly decreased in AD mice, and altered Sox transcription factor expression was also detected. Via this signaling mechanism, physical activity compensated the negative effects of AD on the expression of type IV collagen. Our findings suggest that the testes of AD mice can be a good model of testis degeneration. Moreover, it can be an appropriate organ to follow the effects of various interventions such as physical activity on tissue regeneration and signaling alterations. MDPI 2020-08-10 /pmc/articles/PMC7460847/ /pubmed/32785075 http://dx.doi.org/10.3390/ijms21165726 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szegeczki, Vince
Horváth, Gabriella
Perényi, Helga
Tamás, Andrea
Radák, Zsolt
Ábrahám, Dóra
Zákány, Róza
Reglodi, Dora
Juhász, Tamás
Alzheimer’s Disease Mouse as a Model of Testis Degeneration
title Alzheimer’s Disease Mouse as a Model of Testis Degeneration
title_full Alzheimer’s Disease Mouse as a Model of Testis Degeneration
title_fullStr Alzheimer’s Disease Mouse as a Model of Testis Degeneration
title_full_unstemmed Alzheimer’s Disease Mouse as a Model of Testis Degeneration
title_short Alzheimer’s Disease Mouse as a Model of Testis Degeneration
title_sort alzheimer’s disease mouse as a model of testis degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460847/
https://www.ncbi.nlm.nih.gov/pubmed/32785075
http://dx.doi.org/10.3390/ijms21165726
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