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Alzheimer’s Disease Mouse as a Model of Testis Degeneration
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with protective functions in the central nervous system and various peripheral organs. PACAP has the highest expression level in the testes, among the peripheral organs, and has a positive regulative role in spermatogenesis...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460847/ https://www.ncbi.nlm.nih.gov/pubmed/32785075 http://dx.doi.org/10.3390/ijms21165726 |
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author | Szegeczki, Vince Horváth, Gabriella Perényi, Helga Tamás, Andrea Radák, Zsolt Ábrahám, Dóra Zákány, Róza Reglodi, Dora Juhász, Tamás |
author_facet | Szegeczki, Vince Horváth, Gabriella Perényi, Helga Tamás, Andrea Radák, Zsolt Ábrahám, Dóra Zákány, Róza Reglodi, Dora Juhász, Tamás |
author_sort | Szegeczki, Vince |
collection | PubMed |
description | Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with protective functions in the central nervous system and various peripheral organs. PACAP has the highest expression level in the testes, among the peripheral organs, and has a positive regulative role in spermatogenesis and in sperm motility. In the present study, we explored testicular degenerative alterations in a mouse model of Alzheimer’s disease (AD) (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) and demonstrated changes in PACAP-regulated signaling pathways. In addition, the effects of increased physical activity of AD (trained AD (TAD)) mice on testis were also followed. Reduced cell number and decreased thickness of basement membrane were detected in AD samples. These changes were compensated by physical activity. Expression of PACAP receptors and canonical signaling elements such as PKA, P-PKA, PP2A significantly decreased in AD mice, and altered Sox transcription factor expression was also detected. Via this signaling mechanism, physical activity compensated the negative effects of AD on the expression of type IV collagen. Our findings suggest that the testes of AD mice can be a good model of testis degeneration. Moreover, it can be an appropriate organ to follow the effects of various interventions such as physical activity on tissue regeneration and signaling alterations. |
format | Online Article Text |
id | pubmed-7460847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74608472020-09-14 Alzheimer’s Disease Mouse as a Model of Testis Degeneration Szegeczki, Vince Horváth, Gabriella Perényi, Helga Tamás, Andrea Radák, Zsolt Ábrahám, Dóra Zákány, Róza Reglodi, Dora Juhász, Tamás Int J Mol Sci Article Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with protective functions in the central nervous system and various peripheral organs. PACAP has the highest expression level in the testes, among the peripheral organs, and has a positive regulative role in spermatogenesis and in sperm motility. In the present study, we explored testicular degenerative alterations in a mouse model of Alzheimer’s disease (AD) (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) and demonstrated changes in PACAP-regulated signaling pathways. In addition, the effects of increased physical activity of AD (trained AD (TAD)) mice on testis were also followed. Reduced cell number and decreased thickness of basement membrane were detected in AD samples. These changes were compensated by physical activity. Expression of PACAP receptors and canonical signaling elements such as PKA, P-PKA, PP2A significantly decreased in AD mice, and altered Sox transcription factor expression was also detected. Via this signaling mechanism, physical activity compensated the negative effects of AD on the expression of type IV collagen. Our findings suggest that the testes of AD mice can be a good model of testis degeneration. Moreover, it can be an appropriate organ to follow the effects of various interventions such as physical activity on tissue regeneration and signaling alterations. MDPI 2020-08-10 /pmc/articles/PMC7460847/ /pubmed/32785075 http://dx.doi.org/10.3390/ijms21165726 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Szegeczki, Vince Horváth, Gabriella Perényi, Helga Tamás, Andrea Radák, Zsolt Ábrahám, Dóra Zákány, Róza Reglodi, Dora Juhász, Tamás Alzheimer’s Disease Mouse as a Model of Testis Degeneration |
title | Alzheimer’s Disease Mouse as a Model of Testis Degeneration |
title_full | Alzheimer’s Disease Mouse as a Model of Testis Degeneration |
title_fullStr | Alzheimer’s Disease Mouse as a Model of Testis Degeneration |
title_full_unstemmed | Alzheimer’s Disease Mouse as a Model of Testis Degeneration |
title_short | Alzheimer’s Disease Mouse as a Model of Testis Degeneration |
title_sort | alzheimer’s disease mouse as a model of testis degeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460847/ https://www.ncbi.nlm.nih.gov/pubmed/32785075 http://dx.doi.org/10.3390/ijms21165726 |
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