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COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy
We report a case of a pregnant woman with COVID‐19 who developed coagulopathy in the absence of severe clinical symptoms. A polymerase chain reaction test of a vaginal swab was positive for SARS‐CoV‐2 RNA, suggesting a possibility of perinatal transmission. Cesarean delivery was performed because of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461013/ https://www.ncbi.nlm.nih.gov/pubmed/32853442 http://dx.doi.org/10.1002/uog.22189 |
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author | Mongula, J. E. Frenken, M. W. E. van Lijnschoten, G. Arents, N. L. A. de Wit‐Zuurendonk, L. D. Schimmel‐de Kok, A. P. A. van Runnard Heimel, P. J. Porath, M. M. Goossens, S. M. T. A. |
author_facet | Mongula, J. E. Frenken, M. W. E. van Lijnschoten, G. Arents, N. L. A. de Wit‐Zuurendonk, L. D. Schimmel‐de Kok, A. P. A. van Runnard Heimel, P. J. Porath, M. M. Goossens, S. M. T. A. |
author_sort | Mongula, J. E. |
collection | PubMed |
description | We report a case of a pregnant woman with COVID‐19 who developed coagulopathy in the absence of severe clinical symptoms. A polymerase chain reaction test of a vaginal swab was positive for SARS‐CoV‐2 RNA, suggesting a possibility of perinatal transmission. Cesarean delivery was performed because of a non‐reassuring fetal heart rate; the placenta showed increased perivillous fibrin deposition and intervillositis. Moreover, placental infection with SARS‐CoV‐2 was demonstrated by placental immunostaining. The findings suggest a possible relationship between placental fibrin deposition and chronic and acute intervillositis, non‐reassuring fetal heart rate and coagulopathy in pregnant women with COVID‐19. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. |
format | Online Article Text |
id | pubmed-7461013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-74610132020-09-02 COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy Mongula, J. E. Frenken, M. W. E. van Lijnschoten, G. Arents, N. L. A. de Wit‐Zuurendonk, L. D. Schimmel‐de Kok, A. P. A. van Runnard Heimel, P. J. Porath, M. M. Goossens, S. M. T. A. Ultrasound Obstet Gynecol Case Report We report a case of a pregnant woman with COVID‐19 who developed coagulopathy in the absence of severe clinical symptoms. A polymerase chain reaction test of a vaginal swab was positive for SARS‐CoV‐2 RNA, suggesting a possibility of perinatal transmission. Cesarean delivery was performed because of a non‐reassuring fetal heart rate; the placenta showed increased perivillous fibrin deposition and intervillositis. Moreover, placental infection with SARS‐CoV‐2 was demonstrated by placental immunostaining. The findings suggest a possible relationship between placental fibrin deposition and chronic and acute intervillositis, non‐reassuring fetal heart rate and coagulopathy in pregnant women with COVID‐19. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. John Wiley & Sons, Ltd 2020-10-19 2020-11 /pmc/articles/PMC7461013/ /pubmed/32853442 http://dx.doi.org/10.1002/uog.22189 Text en © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Report Mongula, J. E. Frenken, M. W. E. van Lijnschoten, G. Arents, N. L. A. de Wit‐Zuurendonk, L. D. Schimmel‐de Kok, A. P. A. van Runnard Heimel, P. J. Porath, M. M. Goossens, S. M. T. A. COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy |
title |
COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy |
title_full |
COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy |
title_fullStr |
COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy |
title_full_unstemmed |
COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy |
title_short |
COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy |
title_sort | covid‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461013/ https://www.ncbi.nlm.nih.gov/pubmed/32853442 http://dx.doi.org/10.1002/uog.22189 |
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