Cargando…

COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy

We report a case of a pregnant woman with COVID‐19 who developed coagulopathy in the absence of severe clinical symptoms. A polymerase chain reaction test of a vaginal swab was positive for SARS‐CoV‐2 RNA, suggesting a possibility of perinatal transmission. Cesarean delivery was performed because of...

Descripción completa

Detalles Bibliográficos
Autores principales: Mongula, J. E., Frenken, M. W. E., van Lijnschoten, G., Arents, N. L. A., de Wit‐Zuurendonk, L. D., Schimmel‐de Kok, A. P. A., van Runnard Heimel, P. J., Porath, M. M., Goossens, S. M. T. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461013/
https://www.ncbi.nlm.nih.gov/pubmed/32853442
http://dx.doi.org/10.1002/uog.22189
_version_ 1783576704958070784
author Mongula, J. E.
Frenken, M. W. E.
van Lijnschoten, G.
Arents, N. L. A.
de Wit‐Zuurendonk, L. D.
Schimmel‐de Kok, A. P. A.
van Runnard Heimel, P. J.
Porath, M. M.
Goossens, S. M. T. A.
author_facet Mongula, J. E.
Frenken, M. W. E.
van Lijnschoten, G.
Arents, N. L. A.
de Wit‐Zuurendonk, L. D.
Schimmel‐de Kok, A. P. A.
van Runnard Heimel, P. J.
Porath, M. M.
Goossens, S. M. T. A.
author_sort Mongula, J. E.
collection PubMed
description We report a case of a pregnant woman with COVID‐19 who developed coagulopathy in the absence of severe clinical symptoms. A polymerase chain reaction test of a vaginal swab was positive for SARS‐CoV‐2 RNA, suggesting a possibility of perinatal transmission. Cesarean delivery was performed because of a non‐reassuring fetal heart rate; the placenta showed increased perivillous fibrin deposition and intervillositis. Moreover, placental infection with SARS‐CoV‐2 was demonstrated by placental immunostaining. The findings suggest a possible relationship between placental fibrin deposition and chronic and acute intervillositis, non‐reassuring fetal heart rate and coagulopathy in pregnant women with COVID‐19. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
format Online
Article
Text
id pubmed-7461013
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley & Sons, Ltd
record_format MEDLINE/PubMed
spelling pubmed-74610132020-09-02 COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy Mongula, J. E. Frenken, M. W. E. van Lijnschoten, G. Arents, N. L. A. de Wit‐Zuurendonk, L. D. Schimmel‐de Kok, A. P. A. van Runnard Heimel, P. J. Porath, M. M. Goossens, S. M. T. A. Ultrasound Obstet Gynecol Case Report We report a case of a pregnant woman with COVID‐19 who developed coagulopathy in the absence of severe clinical symptoms. A polymerase chain reaction test of a vaginal swab was positive for SARS‐CoV‐2 RNA, suggesting a possibility of perinatal transmission. Cesarean delivery was performed because of a non‐reassuring fetal heart rate; the placenta showed increased perivillous fibrin deposition and intervillositis. Moreover, placental infection with SARS‐CoV‐2 was demonstrated by placental immunostaining. The findings suggest a possible relationship between placental fibrin deposition and chronic and acute intervillositis, non‐reassuring fetal heart rate and coagulopathy in pregnant women with COVID‐19. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. John Wiley & Sons, Ltd 2020-10-19 2020-11 /pmc/articles/PMC7461013/ /pubmed/32853442 http://dx.doi.org/10.1002/uog.22189 Text en © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Report
Mongula, J. E.
Frenken, M. W. E.
van Lijnschoten, G.
Arents, N. L. A.
de Wit‐Zuurendonk, L. D.
Schimmel‐de Kok, A. P. A.
van Runnard Heimel, P. J.
Porath, M. M.
Goossens, S. M. T. A.
COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy
title COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy
title_full COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy
title_fullStr COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy
title_full_unstemmed COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy
title_short COVID‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy
title_sort covid‐19 during pregnancy: non‐reassuring fetal heart rate, placental pathology and coagulopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461013/
https://www.ncbi.nlm.nih.gov/pubmed/32853442
http://dx.doi.org/10.1002/uog.22189
work_keys_str_mv AT mongulaje covid19duringpregnancynonreassuringfetalheartrateplacentalpathologyandcoagulopathy
AT frenkenmwe covid19duringpregnancynonreassuringfetalheartrateplacentalpathologyandcoagulopathy
AT vanlijnschoteng covid19duringpregnancynonreassuringfetalheartrateplacentalpathologyandcoagulopathy
AT arentsnla covid19duringpregnancynonreassuringfetalheartrateplacentalpathologyandcoagulopathy
AT dewitzuurendonkld covid19duringpregnancynonreassuringfetalheartrateplacentalpathologyandcoagulopathy
AT schimmeldekokapa covid19duringpregnancynonreassuringfetalheartrateplacentalpathologyandcoagulopathy
AT vanrunnardheimelpj covid19duringpregnancynonreassuringfetalheartrateplacentalpathologyandcoagulopathy
AT porathmm covid19duringpregnancynonreassuringfetalheartrateplacentalpathologyandcoagulopathy
AT goossenssmta covid19duringpregnancynonreassuringfetalheartrateplacentalpathologyandcoagulopathy