The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives

Autism spectrum disorders (ASDs) constitute a set of heterogeneous neurodevelopmental conditions, characterized by a wide genetic variability that has led to hypothesize a polygenic origin. The metabolic profiles of patients with ASD suggest a possible implication of mitochondrial pathways. Although...

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Detalles Bibliográficos
Autores principales: Citrigno, Luigi, Muglia, Maria, Qualtieri, Antonio, Spadafora, Patrizia, Cavalcanti, Francesca, Pioggia, Giovanni, Cerasa, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461038/
https://www.ncbi.nlm.nih.gov/pubmed/32806635
http://dx.doi.org/10.3390/ijms21165785
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author Citrigno, Luigi
Muglia, Maria
Qualtieri, Antonio
Spadafora, Patrizia
Cavalcanti, Francesca
Pioggia, Giovanni
Cerasa, Antonio
author_facet Citrigno, Luigi
Muglia, Maria
Qualtieri, Antonio
Spadafora, Patrizia
Cavalcanti, Francesca
Pioggia, Giovanni
Cerasa, Antonio
author_sort Citrigno, Luigi
collection PubMed
description Autism spectrum disorders (ASDs) constitute a set of heterogeneous neurodevelopmental conditions, characterized by a wide genetic variability that has led to hypothesize a polygenic origin. The metabolic profiles of patients with ASD suggest a possible implication of mitochondrial pathways. Although different physiological and biochemical studies reported deficits in mitochondrial oxidative phosphorylation in subjects with ASD, the role of mitochondrial DNA variations has remained relatively unexplored. In this review, we report and discuss very recent evidence to demonstrate the key role of mitochondrial disorders in the development of ASD.
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spelling pubmed-74610382020-09-14 The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives Citrigno, Luigi Muglia, Maria Qualtieri, Antonio Spadafora, Patrizia Cavalcanti, Francesca Pioggia, Giovanni Cerasa, Antonio Int J Mol Sci Review Autism spectrum disorders (ASDs) constitute a set of heterogeneous neurodevelopmental conditions, characterized by a wide genetic variability that has led to hypothesize a polygenic origin. The metabolic profiles of patients with ASD suggest a possible implication of mitochondrial pathways. Although different physiological and biochemical studies reported deficits in mitochondrial oxidative phosphorylation in subjects with ASD, the role of mitochondrial DNA variations has remained relatively unexplored. In this review, we report and discuss very recent evidence to demonstrate the key role of mitochondrial disorders in the development of ASD. MDPI 2020-08-12 /pmc/articles/PMC7461038/ /pubmed/32806635 http://dx.doi.org/10.3390/ijms21165785 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Citrigno, Luigi
Muglia, Maria
Qualtieri, Antonio
Spadafora, Patrizia
Cavalcanti, Francesca
Pioggia, Giovanni
Cerasa, Antonio
The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives
title The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives
title_full The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives
title_fullStr The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives
title_full_unstemmed The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives
title_short The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives
title_sort mitochondrial dysfunction hypothesis in autism spectrum disorders: current status and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461038/
https://www.ncbi.nlm.nih.gov/pubmed/32806635
http://dx.doi.org/10.3390/ijms21165785
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