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Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST

The Wnt/CTNNB1 pathway is often deregulated in epithelial tumors. The ZFP36 gene, encoding the mRNA binding protein Tristetraprolin (TTP), is downregulated in several cancers, where it has been described to behave as a tumor suppressor. By this report, we show that Wnt/CTNNB1 pathway is constitutive...

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Autores principales: Zanfi, Emma D., Fantini, Sebastian, Lotti, Roberta, Bertesi, Matteo, Marconi, Alessandra, Grande, Alexis, Manfredini, Rossella, Pincelli, Carlo, Zanocco-Marani, Tommaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461120/
https://www.ncbi.nlm.nih.gov/pubmed/32784485
http://dx.doi.org/10.3390/ijms21165692
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author Zanfi, Emma D.
Fantini, Sebastian
Lotti, Roberta
Bertesi, Matteo
Marconi, Alessandra
Grande, Alexis
Manfredini, Rossella
Pincelli, Carlo
Zanocco-Marani, Tommaso
author_facet Zanfi, Emma D.
Fantini, Sebastian
Lotti, Roberta
Bertesi, Matteo
Marconi, Alessandra
Grande, Alexis
Manfredini, Rossella
Pincelli, Carlo
Zanocco-Marani, Tommaso
author_sort Zanfi, Emma D.
collection PubMed
description The Wnt/CTNNB1 pathway is often deregulated in epithelial tumors. The ZFP36 gene, encoding the mRNA binding protein Tristetraprolin (TTP), is downregulated in several cancers, where it has been described to behave as a tumor suppressor. By this report, we show that Wnt/CTNNB1 pathway is constitutively activated, and ZFP36 expression is downregulated in Squamous Cell Carcinoma (SCC) cell lines compared to normal keratinocytes. Moreover, we suggest that the decrease of ZFP36 expression might depend on the activity of transcriptional repressors SNAI1, SLUG and TWIST, whose expression is induced by Wnt/CTNNB1, highlighting a potential regulatory mechanism underlying ZFP36 downregulation in epithelial cancers.
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spelling pubmed-74611202020-09-14 Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST Zanfi, Emma D. Fantini, Sebastian Lotti, Roberta Bertesi, Matteo Marconi, Alessandra Grande, Alexis Manfredini, Rossella Pincelli, Carlo Zanocco-Marani, Tommaso Int J Mol Sci Article The Wnt/CTNNB1 pathway is often deregulated in epithelial tumors. The ZFP36 gene, encoding the mRNA binding protein Tristetraprolin (TTP), is downregulated in several cancers, where it has been described to behave as a tumor suppressor. By this report, we show that Wnt/CTNNB1 pathway is constitutively activated, and ZFP36 expression is downregulated in Squamous Cell Carcinoma (SCC) cell lines compared to normal keratinocytes. Moreover, we suggest that the decrease of ZFP36 expression might depend on the activity of transcriptional repressors SNAI1, SLUG and TWIST, whose expression is induced by Wnt/CTNNB1, highlighting a potential regulatory mechanism underlying ZFP36 downregulation in epithelial cancers. MDPI 2020-08-08 /pmc/articles/PMC7461120/ /pubmed/32784485 http://dx.doi.org/10.3390/ijms21165692 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zanfi, Emma D.
Fantini, Sebastian
Lotti, Roberta
Bertesi, Matteo
Marconi, Alessandra
Grande, Alexis
Manfredini, Rossella
Pincelli, Carlo
Zanocco-Marani, Tommaso
Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST
title Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST
title_full Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST
title_fullStr Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST
title_full_unstemmed Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST
title_short Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST
title_sort wnt/ctnnb1 signal transduction pathway inhibits the expression of zfp36 in squamous cell carcinoma, by inducing transcriptional repressors snai1, slug and twist
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461120/
https://www.ncbi.nlm.nih.gov/pubmed/32784485
http://dx.doi.org/10.3390/ijms21165692
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