Allosteric Inhibition of the SARS‐CoV‐2 Main Protease: Insights from Mass Spectrometry Based Assays

The SARS‐CoV‐2 main protease (M(pro)) cleaves along the two viral polypeptides to release non‐structural proteins required for viral replication. M(Pro) is an attractive target for antiviral therapies to combat the coronavirus‐2019 disease. Here, we used native mass spectrometry to characterize the...

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Detalles Bibliográficos
Autores principales: El‐Baba, Tarick J., Lutomski, Corinne A., Kantsadi, Anastassia L., Malla, Tika R., John, Tobias, Mikhailov, Victor, Bolla, Jani R., Schofield, Christopher J., Zitzmann, Nicole, Vakonakis, Ioannis, Robinson, Carol V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461284/
https://www.ncbi.nlm.nih.gov/pubmed/32841477
http://dx.doi.org/10.1002/anie.202010316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461284/
https://www.ncbi.nlm.nih.gov/pubmed/32841477
http://dx.doi.org/10.1002/anie.202010316

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