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Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2
To inform seroepidemiological studies, we characterized the IgG‐ responses in COVID‐19 patients against the two major SARS‐CoV‐2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 COVID‐19 sera collected up to 85 days post‐symptom onset and 230 non‐COVID‐19 sera, including 27 SARS sera fro...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461388/ https://www.ncbi.nlm.nih.gov/pubmed/32844604 http://dx.doi.org/10.1111/irv.12798 |
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| author | Xiao, Cheng Ling, Shiman Qiu, Minshan Deng, Zhenxuan Chen, Liping Zhu, Airu Chen, Yi Liu, Yong Lin, Xia Lin, Fangmei Wu, Qiubao Shen, Lihan Ye, Feng Liu, Xiaoqing Li, Yimin Zhao, Jincun Yang, Zifeng Cowling, Benjamin J. Webby, Richard Zanin, Mark Wong, Sook‐San |
| author_facet | Xiao, Cheng Ling, Shiman Qiu, Minshan Deng, Zhenxuan Chen, Liping Zhu, Airu Chen, Yi Liu, Yong Lin, Xia Lin, Fangmei Wu, Qiubao Shen, Lihan Ye, Feng Liu, Xiaoqing Li, Yimin Zhao, Jincun Yang, Zifeng Cowling, Benjamin J. Webby, Richard Zanin, Mark Wong, Sook‐San |
| author_sort | Xiao, Cheng |
| collection | PubMed |
| description | To inform seroepidemiological studies, we characterized the IgG‐ responses in COVID‐19 patients against the two major SARS‐CoV‐2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 COVID‐19 sera collected up to 85 days post‐symptom onset and 230 non‐COVID‐19 sera, including 27 SARS sera from 2003. Although the average SARS‐CoV‐2 S and N‐IgG titers were comparable, N‐responses were more variable among individuals. S‐ and N‐assay specificity tested with non‐COVID‐19 sera were comparable at 97.5% and 97.0%, respectively. Therefore, S will make a better target due to its lower cross‐reactive potential and its' more consistent frequency of detection compared to N. |
| format | Online Article Text |
| id | pubmed-7461388 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74613882020-09-02 Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2 Xiao, Cheng Ling, Shiman Qiu, Minshan Deng, Zhenxuan Chen, Liping Zhu, Airu Chen, Yi Liu, Yong Lin, Xia Lin, Fangmei Wu, Qiubao Shen, Lihan Ye, Feng Liu, Xiaoqing Li, Yimin Zhao, Jincun Yang, Zifeng Cowling, Benjamin J. Webby, Richard Zanin, Mark Wong, Sook‐San Influenza Other Respir Viruses Short Articles To inform seroepidemiological studies, we characterized the IgG‐ responses in COVID‐19 patients against the two major SARS‐CoV‐2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 COVID‐19 sera collected up to 85 days post‐symptom onset and 230 non‐COVID‐19 sera, including 27 SARS sera from 2003. Although the average SARS‐CoV‐2 S and N‐IgG titers were comparable, N‐responses were more variable among individuals. S‐ and N‐assay specificity tested with non‐COVID‐19 sera were comparable at 97.5% and 97.0%, respectively. Therefore, S will make a better target due to its lower cross‐reactive potential and its' more consistent frequency of detection compared to N. John Wiley and Sons Inc. 2020-08-25 2021-01 /pmc/articles/PMC7461388/ /pubmed/32844604 http://dx.doi.org/10.1111/irv.12798 Text en © 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Short Articles Xiao, Cheng Ling, Shiman Qiu, Minshan Deng, Zhenxuan Chen, Liping Zhu, Airu Chen, Yi Liu, Yong Lin, Xia Lin, Fangmei Wu, Qiubao Shen, Lihan Ye, Feng Liu, Xiaoqing Li, Yimin Zhao, Jincun Yang, Zifeng Cowling, Benjamin J. Webby, Richard Zanin, Mark Wong, Sook‐San Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2 |
| title | Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2 |
| title_full | Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2 |
| title_fullStr | Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2 |
| title_full_unstemmed | Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2 |
| title_short | Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2 |
| title_sort | human post‐infection serological response to the spike and nucleocapsid proteins of sars‐cov‐2 |
| topic | Short Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461388/ https://www.ncbi.nlm.nih.gov/pubmed/32844604 http://dx.doi.org/10.1111/irv.12798 |
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