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Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis

Low-dose radiation therapy (LDRT) has been successfully established for decades as an alternative analgesic treatment option for patients suffering from chronic degenerative and inflammatory diseases. In this study, 483 patients were undergoing LDRT for degenerative joint disease of the fingers and...

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Autores principales: Donaubauer, Anna-Jasmina, Zhou, Jian-Guo, Ott, Oliver J., Putz, Florian, Fietkau, Rainer, Keilholz, Ludwig, Gaipl, Udo S., Frey, Benjamin, Weissmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461565/
https://www.ncbi.nlm.nih.gov/pubmed/32824064
http://dx.doi.org/10.3390/ijms21165854
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author Donaubauer, Anna-Jasmina
Zhou, Jian-Guo
Ott, Oliver J.
Putz, Florian
Fietkau, Rainer
Keilholz, Ludwig
Gaipl, Udo S.
Frey, Benjamin
Weissmann, Thomas
author_facet Donaubauer, Anna-Jasmina
Zhou, Jian-Guo
Ott, Oliver J.
Putz, Florian
Fietkau, Rainer
Keilholz, Ludwig
Gaipl, Udo S.
Frey, Benjamin
Weissmann, Thomas
author_sort Donaubauer, Anna-Jasmina
collection PubMed
description Low-dose radiation therapy (LDRT) has been successfully established for decades as an alternative analgesic treatment option for patients suffering from chronic degenerative and inflammatory diseases. In this study, 483 patients were undergoing LDRT for degenerative joint disease of the fingers and thumb at the University Hospital Erlangen between 2004 and 2019. Radiotherapy was applied according to the German guidelines for LDRT. Several impact factors on therapeutic success, such as the age and gender, the number of affected fingers, the single and cumulative dose, as well as the number of series, were investigated. In summary, 70% of the patients showed an improvement of their pain following LDRT. No significant impact was found for the factors age, gender, the number of series or the cumulative dosage. Patients with an involvement of the thumb showed a significantly worse outcome compared to patients with an isolated affection of the fingers. In this cohort, patients receiving a single dose of 0.5 Gy reported a significantly better outcome than patients receiving 1.0 Gy, strongly suggesting a reduction in the total dose. In summary, LDRT is a good alternative treatment option for patients suffering from degenerative and inflammatory joint disease of the fingers.
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spelling pubmed-74615652020-09-04 Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis Donaubauer, Anna-Jasmina Zhou, Jian-Guo Ott, Oliver J. Putz, Florian Fietkau, Rainer Keilholz, Ludwig Gaipl, Udo S. Frey, Benjamin Weissmann, Thomas Int J Mol Sci Article Low-dose radiation therapy (LDRT) has been successfully established for decades as an alternative analgesic treatment option for patients suffering from chronic degenerative and inflammatory diseases. In this study, 483 patients were undergoing LDRT for degenerative joint disease of the fingers and thumb at the University Hospital Erlangen between 2004 and 2019. Radiotherapy was applied according to the German guidelines for LDRT. Several impact factors on therapeutic success, such as the age and gender, the number of affected fingers, the single and cumulative dose, as well as the number of series, were investigated. In summary, 70% of the patients showed an improvement of their pain following LDRT. No significant impact was found for the factors age, gender, the number of series or the cumulative dosage. Patients with an involvement of the thumb showed a significantly worse outcome compared to patients with an isolated affection of the fingers. In this cohort, patients receiving a single dose of 0.5 Gy reported a significantly better outcome than patients receiving 1.0 Gy, strongly suggesting a reduction in the total dose. In summary, LDRT is a good alternative treatment option for patients suffering from degenerative and inflammatory joint disease of the fingers. MDPI 2020-08-14 /pmc/articles/PMC7461565/ /pubmed/32824064 http://dx.doi.org/10.3390/ijms21165854 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Donaubauer, Anna-Jasmina
Zhou, Jian-Guo
Ott, Oliver J.
Putz, Florian
Fietkau, Rainer
Keilholz, Ludwig
Gaipl, Udo S.
Frey, Benjamin
Weissmann, Thomas
Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis
title Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis
title_full Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis
title_fullStr Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis
title_full_unstemmed Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis
title_short Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis
title_sort low dose radiation therapy, particularly with 0.5 gy, improves pain in degenerative joint disease of the fingers: results of a retrospective analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461565/
https://www.ncbi.nlm.nih.gov/pubmed/32824064
http://dx.doi.org/10.3390/ijms21165854
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