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Experimental animal models of post-traumatic osteoarthritis of the knee
Due to the complex and dynamic nature of osteoarthritis (OA) and post-traumatic osteoarthritis (PTOA), animal models have been used to investigate the progression and pathogenesis of the disease. Researchers have used different experimental models to study OA and PTOA. With an emphasis on the knee j...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461640/ https://www.ncbi.nlm.nih.gov/pubmed/32922696 http://dx.doi.org/10.4081/or.2020.8448 |
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author | Narez, Gerardo E. Fischenich, Kristine M. Donahue, Tammy L. Haut |
author_facet | Narez, Gerardo E. Fischenich, Kristine M. Donahue, Tammy L. Haut |
author_sort | Narez, Gerardo E. |
collection | PubMed |
description | Due to the complex and dynamic nature of osteoarthritis (OA) and post-traumatic osteoarthritis (PTOA), animal models have been used to investigate the progression and pathogenesis of the disease. Researchers have used different experimental models to study OA and PTOA. With an emphasis on the knee joint, this review will compare and contrast the existing body of knowledge from anterior cruciate ligament transection models, meniscectomy models, combination models, as well as impact models in large animals to see how tissues respond to these different approaches to induce experimental OA and PTOA. The tissues discussed will include articular cartilage and the meniscus, with a focus on morphological, mechanical and histological assessments. The goal of this review is to demonstrate the progressive nature of OA by indicating the strong correlation between progressive tissue degeneration, change of mechanical properties, and loss of biochemical integrity and to highlight key differences between the most commonly used experimental animal models. |
format | Online Article Text |
id | pubmed-7461640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-74616402020-09-10 Experimental animal models of post-traumatic osteoarthritis of the knee Narez, Gerardo E. Fischenich, Kristine M. Donahue, Tammy L. Haut Orthop Rev (Pavia) Review Due to the complex and dynamic nature of osteoarthritis (OA) and post-traumatic osteoarthritis (PTOA), animal models have been used to investigate the progression and pathogenesis of the disease. Researchers have used different experimental models to study OA and PTOA. With an emphasis on the knee joint, this review will compare and contrast the existing body of knowledge from anterior cruciate ligament transection models, meniscectomy models, combination models, as well as impact models in large animals to see how tissues respond to these different approaches to induce experimental OA and PTOA. The tissues discussed will include articular cartilage and the meniscus, with a focus on morphological, mechanical and histological assessments. The goal of this review is to demonstrate the progressive nature of OA by indicating the strong correlation between progressive tissue degeneration, change of mechanical properties, and loss of biochemical integrity and to highlight key differences between the most commonly used experimental animal models. PAGEPress Publications, Pavia, Italy 2020-08-06 /pmc/articles/PMC7461640/ /pubmed/32922696 http://dx.doi.org/10.4081/or.2020.8448 Text en ©Copyright: the Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution NonCommercial 4.0 License (CC BY-NC 4.0). |
spellingShingle | Review Narez, Gerardo E. Fischenich, Kristine M. Donahue, Tammy L. Haut Experimental animal models of post-traumatic osteoarthritis of the knee |
title | Experimental animal models of post-traumatic osteoarthritis of the knee |
title_full | Experimental animal models of post-traumatic osteoarthritis of the knee |
title_fullStr | Experimental animal models of post-traumatic osteoarthritis of the knee |
title_full_unstemmed | Experimental animal models of post-traumatic osteoarthritis of the knee |
title_short | Experimental animal models of post-traumatic osteoarthritis of the knee |
title_sort | experimental animal models of post-traumatic osteoarthritis of the knee |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461640/ https://www.ncbi.nlm.nih.gov/pubmed/32922696 http://dx.doi.org/10.4081/or.2020.8448 |
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