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Role of Vitamin D in Prevention of Food Allergy in Infants
The prevalence of food allergy is increasing over the last decades. The role of vitamin D in the prevention of food allergy has been largely investigated. Its role on the physiology of calcium and bone is known, but calcitriol (active form of the vitamin D) also influences the epithelial cells, T ce...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461773/ https://www.ncbi.nlm.nih.gov/pubmed/33014916 http://dx.doi.org/10.3389/fped.2020.00447 |
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author | Giannetti, Arianna Bernardini, Luca Cangemi, Jessica Gallucci, Marcella Masetti, Riccardo Ricci, Giampaolo |
author_facet | Giannetti, Arianna Bernardini, Luca Cangemi, Jessica Gallucci, Marcella Masetti, Riccardo Ricci, Giampaolo |
author_sort | Giannetti, Arianna |
collection | PubMed |
description | The prevalence of food allergy is increasing over the last decades. The role of vitamin D in the prevention of food allergy has been largely investigated. Its role on the physiology of calcium and bone is known, but calcitriol (active form of the vitamin D) also influences the epithelial cells, T cells, B cells, macrophages, and dendritic cells. Almost all cells of the adaptive immune system express the vitamin D receptor, making them also capable of being vitamin responsive. Specifically considering the potential role of vitamins in food allergy, vitamin D has been shown to affect several mechanisms that promote immunologic tolerance, including the T regulatory cell function and the induction of tolerogenic dendritic cells. The target of our review is to evaluate the role of vitamin D in the prevention of food allergy in children. There are contradictory data on the relationship among the vitamin D deficiency and the developing of food allergy. Some studies associate lower exposure to sunlight to food allergy; on the other hand, further research has found that higher vitamin D levels could increase the likelihood of allergic sensitization and food allergy. Therefore, there is an urgent need for well-planned randomized controlled trials on vitamin D supplementation, with particular regard to the prevention of food allergy. The role of vitamin D beyond bone and calcium metabolism is not fully understood. |
format | Online Article Text |
id | pubmed-7461773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74617732020-10-01 Role of Vitamin D in Prevention of Food Allergy in Infants Giannetti, Arianna Bernardini, Luca Cangemi, Jessica Gallucci, Marcella Masetti, Riccardo Ricci, Giampaolo Front Pediatr Pediatrics The prevalence of food allergy is increasing over the last decades. The role of vitamin D in the prevention of food allergy has been largely investigated. Its role on the physiology of calcium and bone is known, but calcitriol (active form of the vitamin D) also influences the epithelial cells, T cells, B cells, macrophages, and dendritic cells. Almost all cells of the adaptive immune system express the vitamin D receptor, making them also capable of being vitamin responsive. Specifically considering the potential role of vitamins in food allergy, vitamin D has been shown to affect several mechanisms that promote immunologic tolerance, including the T regulatory cell function and the induction of tolerogenic dendritic cells. The target of our review is to evaluate the role of vitamin D in the prevention of food allergy in children. There are contradictory data on the relationship among the vitamin D deficiency and the developing of food allergy. Some studies associate lower exposure to sunlight to food allergy; on the other hand, further research has found that higher vitamin D levels could increase the likelihood of allergic sensitization and food allergy. Therefore, there is an urgent need for well-planned randomized controlled trials on vitamin D supplementation, with particular regard to the prevention of food allergy. The role of vitamin D beyond bone and calcium metabolism is not fully understood. Frontiers Media S.A. 2020-08-18 /pmc/articles/PMC7461773/ /pubmed/33014916 http://dx.doi.org/10.3389/fped.2020.00447 Text en Copyright © 2020 Giannetti, Bernardini, Cangemi, Gallucci, Masetti and Ricci. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Giannetti, Arianna Bernardini, Luca Cangemi, Jessica Gallucci, Marcella Masetti, Riccardo Ricci, Giampaolo Role of Vitamin D in Prevention of Food Allergy in Infants |
title | Role of Vitamin D in Prevention of Food Allergy in Infants |
title_full | Role of Vitamin D in Prevention of Food Allergy in Infants |
title_fullStr | Role of Vitamin D in Prevention of Food Allergy in Infants |
title_full_unstemmed | Role of Vitamin D in Prevention of Food Allergy in Infants |
title_short | Role of Vitamin D in Prevention of Food Allergy in Infants |
title_sort | role of vitamin d in prevention of food allergy in infants |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461773/ https://www.ncbi.nlm.nih.gov/pubmed/33014916 http://dx.doi.org/10.3389/fped.2020.00447 |
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