The Molecular Mechanisms That Underlie the Immune Biology of Anti-drug Antibody Formation Following Treatment With Monoclonal Antibodies

Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine, however, the repeated administration of mAbs can be highly immunogenic. Drug immunogenicity manifests in the generation of anti-drug antibodies (ADAs), and some mAbs show immunogenicity in up to 70% of patients. A...

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Detalles Bibliográficos
Autores principales: Vaisman-Mentesh, Anna, Gutierrez-Gonzalez, Matias, DeKosky, Brandon J., Wine, Yariv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461797/
https://www.ncbi.nlm.nih.gov/pubmed/33013848
http://dx.doi.org/10.3389/fimmu.2020.01951

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