The Role of VP16 in the Life Cycle of Alphaherpesviruses

The protein encoded by the UL48 gene of alphaherpesviruses is named VP16 or alpha-gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important transactivator that can activate the transcription of viral immediate-early genes, and in the late stage of viral repli...

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Autores principales: Fan, Dengjian, Wang, Mingshu, Cheng, Anchun, Jia, Renyong, Yang, Qiao, Wu, Ying, Zhu, Dekang, Zhao, Xinxin, Chen, Shun, Liu, Mafeng, Zhang, Shaqiu, Ou, Xumin, Mao, Sai, Gao, Qun, Sun, Di, Wen, Xingjian, Liu, Yunya, Yu, Yanling, Zhang, Ling, Tian, Bin, Pan, Leichang, Chen, Xiaoyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461839/
https://www.ncbi.nlm.nih.gov/pubmed/33013729
http://dx.doi.org/10.3389/fmicb.2020.01910
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author Fan, Dengjian
Wang, Mingshu
Cheng, Anchun
Jia, Renyong
Yang, Qiao
Wu, Ying
Zhu, Dekang
Zhao, Xinxin
Chen, Shun
Liu, Mafeng
Zhang, Shaqiu
Ou, Xumin
Mao, Sai
Gao, Qun
Sun, Di
Wen, Xingjian
Liu, Yunya
Yu, Yanling
Zhang, Ling
Tian, Bin
Pan, Leichang
Chen, Xiaoyue
author_facet Fan, Dengjian
Wang, Mingshu
Cheng, Anchun
Jia, Renyong
Yang, Qiao
Wu, Ying
Zhu, Dekang
Zhao, Xinxin
Chen, Shun
Liu, Mafeng
Zhang, Shaqiu
Ou, Xumin
Mao, Sai
Gao, Qun
Sun, Di
Wen, Xingjian
Liu, Yunya
Yu, Yanling
Zhang, Ling
Tian, Bin
Pan, Leichang
Chen, Xiaoyue
author_sort Fan, Dengjian
collection PubMed
description The protein encoded by the UL48 gene of alphaherpesviruses is named VP16 or alpha-gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important transactivator that can activate the transcription of viral immediate-early genes, and in the late stage of viral replication, VP16, as a tegument, is involved in viral assembly. This review will explain the mechanism of VP16 acting as α-TIF to activate the transcription of viral immediate-early genes, its role in the transition from viral latency to reactivation, and its effects on viral assembly and maturation. In addition, this review also provides new insights for further research on the life cycle of alphaherpesviruses and the role of VP16 in the viral life cycle.
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spelling pubmed-74618392020-10-01 The Role of VP16 in the Life Cycle of Alphaherpesviruses Fan, Dengjian Wang, Mingshu Cheng, Anchun Jia, Renyong Yang, Qiao Wu, Ying Zhu, Dekang Zhao, Xinxin Chen, Shun Liu, Mafeng Zhang, Shaqiu Ou, Xumin Mao, Sai Gao, Qun Sun, Di Wen, Xingjian Liu, Yunya Yu, Yanling Zhang, Ling Tian, Bin Pan, Leichang Chen, Xiaoyue Front Microbiol Microbiology The protein encoded by the UL48 gene of alphaherpesviruses is named VP16 or alpha-gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important transactivator that can activate the transcription of viral immediate-early genes, and in the late stage of viral replication, VP16, as a tegument, is involved in viral assembly. This review will explain the mechanism of VP16 acting as α-TIF to activate the transcription of viral immediate-early genes, its role in the transition from viral latency to reactivation, and its effects on viral assembly and maturation. In addition, this review also provides new insights for further research on the life cycle of alphaherpesviruses and the role of VP16 in the viral life cycle. Frontiers Media S.A. 2020-08-18 /pmc/articles/PMC7461839/ /pubmed/33013729 http://dx.doi.org/10.3389/fmicb.2020.01910 Text en Copyright © 2020 Fan, Wang, Cheng, Jia, Yang, Wu, Zhu, Zhao, Chen, Liu, Zhang, Ou, Mao, Gao, Sun, Wen, Liu, Yu, Zhang, Tian, Pan and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Fan, Dengjian
Wang, Mingshu
Cheng, Anchun
Jia, Renyong
Yang, Qiao
Wu, Ying
Zhu, Dekang
Zhao, Xinxin
Chen, Shun
Liu, Mafeng
Zhang, Shaqiu
Ou, Xumin
Mao, Sai
Gao, Qun
Sun, Di
Wen, Xingjian
Liu, Yunya
Yu, Yanling
Zhang, Ling
Tian, Bin
Pan, Leichang
Chen, Xiaoyue
The Role of VP16 in the Life Cycle of Alphaherpesviruses
title The Role of VP16 in the Life Cycle of Alphaherpesviruses
title_full The Role of VP16 in the Life Cycle of Alphaherpesviruses
title_fullStr The Role of VP16 in the Life Cycle of Alphaherpesviruses
title_full_unstemmed The Role of VP16 in the Life Cycle of Alphaherpesviruses
title_short The Role of VP16 in the Life Cycle of Alphaherpesviruses
title_sort role of vp16 in the life cycle of alphaherpesviruses
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461839/
https://www.ncbi.nlm.nih.gov/pubmed/33013729
http://dx.doi.org/10.3389/fmicb.2020.01910
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