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Biased MAIT TCR Usage Poised for Limited Antigen Diversity?
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize the evolutionarily conserved major histocompatibility complex (MHC) class I-like antigen-presenting molecule known as MHC class I related protein 1 (MR1). Since their rise from obscurity in the early 19...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461848/ https://www.ncbi.nlm.nih.gov/pubmed/33013835 http://dx.doi.org/10.3389/fimmu.2020.01845 |
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author | Souter, Michael N. T. Eckle, Sidonia B. G. |
author_facet | Souter, Michael N. T. Eckle, Sidonia B. G. |
author_sort | Souter, Michael N. T. |
collection | PubMed |
description | Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize the evolutionarily conserved major histocompatibility complex (MHC) class I-like antigen-presenting molecule known as MHC class I related protein 1 (MR1). Since their rise from obscurity in the early 1990s, the study of MAIT cells has grown substantially, accelerating our fundamental understanding of these cells and their possible roles in immunity. In the context of recent advances, we review here the relationship between MR1, antigen, and TCR usage among MAIT and other MR1-reactive T cells and provide a speculative discussion. |
format | Online Article Text |
id | pubmed-7461848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74618482020-10-01 Biased MAIT TCR Usage Poised for Limited Antigen Diversity? Souter, Michael N. T. Eckle, Sidonia B. G. Front Immunol Immunology Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize the evolutionarily conserved major histocompatibility complex (MHC) class I-like antigen-presenting molecule known as MHC class I related protein 1 (MR1). Since their rise from obscurity in the early 1990s, the study of MAIT cells has grown substantially, accelerating our fundamental understanding of these cells and their possible roles in immunity. In the context of recent advances, we review here the relationship between MR1, antigen, and TCR usage among MAIT and other MR1-reactive T cells and provide a speculative discussion. Frontiers Media S.A. 2020-08-18 /pmc/articles/PMC7461848/ /pubmed/33013835 http://dx.doi.org/10.3389/fimmu.2020.01845 Text en Copyright © 2020 Souter and Eckle. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Souter, Michael N. T. Eckle, Sidonia B. G. Biased MAIT TCR Usage Poised for Limited Antigen Diversity? |
title | Biased MAIT TCR Usage Poised for Limited Antigen Diversity? |
title_full | Biased MAIT TCR Usage Poised for Limited Antigen Diversity? |
title_fullStr | Biased MAIT TCR Usage Poised for Limited Antigen Diversity? |
title_full_unstemmed | Biased MAIT TCR Usage Poised for Limited Antigen Diversity? |
title_short | Biased MAIT TCR Usage Poised for Limited Antigen Diversity? |
title_sort | biased mait tcr usage poised for limited antigen diversity? |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461848/ https://www.ncbi.nlm.nih.gov/pubmed/33013835 http://dx.doi.org/10.3389/fimmu.2020.01845 |
work_keys_str_mv | AT soutermichaelnt biasedmaittcrusagepoisedforlimitedantigendiversity AT ecklesidoniabg biasedmaittcrusagepoisedforlimitedantigendiversity |