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Augmenting the Effectiveness of CAR-T Cells by Enhanced Self-Delivery of PD-1-Neutralizing scFv

Chimeric antigen receptor T (CAR-T) cell therapy is not satisfying in solid tumors. PD-1-mediated suppression greatly hinders CAR-T cells in the microenvironment. It has been shown that PD-1 blockade improves the effectiveness of CAR-T cells. Herein, we designed CAR-T cells than could secret α-PD-1...

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Detalles Bibliográficos
Autores principales:	Ping, Yu, Li, Feng, Nan, Shufeng, Zhang, Daiqun, Shi, Xiaojuan, Shan, Jiqi, Zhang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461868/ https://www.ncbi.nlm.nih.gov/pubmed/32974346 http://dx.doi.org/10.3389/fcell.2020.00803

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