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Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis

Loss of function mutations in the progranulin (PGRN) gene is a risk factor for Alzheimer’s disease (AD). Previous works reported that the deficiency of PGRN accelerates β-amyloid (Aβ) accumulation in AD transgenic mouse brains while overexpression of PGRN could restrain disease progression. However,...

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Detalles Bibliográficos
Autores principales:	Guan, Zhangxin, Chen, Zuolong, Fu, Shumei, Dai, Linbin, Shen, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461932/ https://www.ncbi.nlm.nih.gov/pubmed/32973454 http://dx.doi.org/10.3389/fncel.2020.00260

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