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Viral Transmission and Clinical Features in Asymptomatic Carriers of SARS-CoV-2 in Wuhan, China

We report the clinical characteristics, viral shedding duration, and contact tracing for asymptomatic carriers of SARS-CoV-2 in Wuhan, China. The asymptomatic carriers were relatively young (median age: 34.5 years). Chest computed tomography showed no abnormalities. The nasopharyngeal swab was an op...

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Autores principales: Tan, Fen, Wang, Kaige, Liu, Jiasheng, Liu, Dan, Luo, Jianfei, Zhou, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461982/
https://www.ncbi.nlm.nih.gov/pubmed/33015099
http://dx.doi.org/10.3389/fmed.2020.00547
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author Tan, Fen
Wang, Kaige
Liu, Jiasheng
Liu, Dan
Luo, Jianfei
Zhou, Rui
author_facet Tan, Fen
Wang, Kaige
Liu, Jiasheng
Liu, Dan
Luo, Jianfei
Zhou, Rui
author_sort Tan, Fen
collection PubMed
description We report the clinical characteristics, viral shedding duration, and contact tracing for asymptomatic carriers of SARS-CoV-2 in Wuhan, China. The asymptomatic carriers were relatively young (median age: 34.5 years). Chest computed tomography showed no abnormalities. The nasopharyngeal swab was an optimum specimen for RNA testing. The median viral shedding duration was 11.5 days. Notably, 2 months of viral shedding duration were reported in two nurses, which was much longer than previously reported or than usually thought. The transmissibility of SARS-CoV-2 by asymptomatic carriers during the studied period in Wuhan appeared to be weak. Only one patient (1/12) was found to have transmitted the virus to another person. Early asymptomatic carrier detection, isolation, and contact tracing could be useful to mitigate the spread of the disease.
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spelling pubmed-74619822020-10-01 Viral Transmission and Clinical Features in Asymptomatic Carriers of SARS-CoV-2 in Wuhan, China Tan, Fen Wang, Kaige Liu, Jiasheng Liu, Dan Luo, Jianfei Zhou, Rui Front Med (Lausanne) Medicine We report the clinical characteristics, viral shedding duration, and contact tracing for asymptomatic carriers of SARS-CoV-2 in Wuhan, China. The asymptomatic carriers were relatively young (median age: 34.5 years). Chest computed tomography showed no abnormalities. The nasopharyngeal swab was an optimum specimen for RNA testing. The median viral shedding duration was 11.5 days. Notably, 2 months of viral shedding duration were reported in two nurses, which was much longer than previously reported or than usually thought. The transmissibility of SARS-CoV-2 by asymptomatic carriers during the studied period in Wuhan appeared to be weak. Only one patient (1/12) was found to have transmitted the virus to another person. Early asymptomatic carrier detection, isolation, and contact tracing could be useful to mitigate the spread of the disease. Frontiers Media S.A. 2020-08-18 /pmc/articles/PMC7461982/ /pubmed/33015099 http://dx.doi.org/10.3389/fmed.2020.00547 Text en Copyright © 2020 Tan, Wang, Liu, Liu, Luo and Zhou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Tan, Fen
Wang, Kaige
Liu, Jiasheng
Liu, Dan
Luo, Jianfei
Zhou, Rui
Viral Transmission and Clinical Features in Asymptomatic Carriers of SARS-CoV-2 in Wuhan, China
title Viral Transmission and Clinical Features in Asymptomatic Carriers of SARS-CoV-2 in Wuhan, China
title_full Viral Transmission and Clinical Features in Asymptomatic Carriers of SARS-CoV-2 in Wuhan, China
title_fullStr Viral Transmission and Clinical Features in Asymptomatic Carriers of SARS-CoV-2 in Wuhan, China
title_full_unstemmed Viral Transmission and Clinical Features in Asymptomatic Carriers of SARS-CoV-2 in Wuhan, China
title_short Viral Transmission and Clinical Features in Asymptomatic Carriers of SARS-CoV-2 in Wuhan, China
title_sort viral transmission and clinical features in asymptomatic carriers of sars-cov-2 in wuhan, china
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461982/
https://www.ncbi.nlm.nih.gov/pubmed/33015099
http://dx.doi.org/10.3389/fmed.2020.00547
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