Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice

Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes. However, the mechanisms that trigger the underlying adipose tissues inflammation are not completely understood. Here, we show that the E3 ubiquitin ligase March1 controls the phenotypic and functional prope...

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Detalles Bibliográficos
Autores principales: Majdoubi, Abdelilah, Lee, Jun Seong, Kishta, Osama A., Balood, Mohammad, Moulefera, Mohamed Abdelwafi, Ishido, Satoshi, Talbot, Sébastien, Cheong, Cheolho, Alquier, Thierry, Thibodeau, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461985/
https://www.ncbi.nlm.nih.gov/pubmed/32973799
http://dx.doi.org/10.3389/fimmu.2020.01953

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