MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity

Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer characterized by initial chemosensitivity followed by emergence of chemoresistant disease. To study roles for MYCN amplification in SCLC progression and chemoresistance, we developed a genetically engineered mouse model of MYCN-ove...

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Detalles Bibliográficos
Autores principales: Grunblatt, Eli, Wu, Nan, Zhang, Huajia, Liu, Xiaoli, Norton, Justin P., Ohol, Yamini, Leger, Paul, Hiatt, Joseph B., Eastwood, Emily C., Thomas, Rhiana, Ibrahim, Ali H., Jia, Deshui, Basom, Ryan, Eaton, Keith D., Martins, Renato, Houghton, A. McGarry, MacPherson, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462062/
https://www.ncbi.nlm.nih.gov/pubmed/32820040
http://dx.doi.org/10.1101/gad.340133.120

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