Functional loss of a noncanonical BCOR–PRC1.1 complex accelerates SHH-driven medulloblastoma formation

Medulloblastoma is a malignant childhood brain tumor arising from the developing cerebellum. In Sonic Hedgehog (SHH) subgroup medulloblastoma, aberrant activation of SHH signaling causes increased proliferation of granule neuron progenitors (GNPs), and predisposes these cells to tumorigenesis. A sec...

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Detalles Bibliográficos
Autores principales: Kutscher, Lena M., Okonechnikov, Konstantin, Batora, Nadja V., Clark, Jessica, Silva, Patricia B.G., Vouri, Mikaella, van Rijn, Sjoerd, Sieber, Laura, Statz, Britta, Gearhart, Micah D., Shiraishi, Ryo, Mack, Norman, Orr, Brent A., Korshunov, Andrey, Gudenas, Brian L., Smith, Kyle S., Mercier, Audrey L., Ayrault, Olivier, Hoshino, Mikio, Kool, Marcel, von Hoff, Katja, Graf, Norbert, Fleischhack, Gudrun, Bardwell, Vivian J., Pfister, Stefan M., Northcott, Paul A., Kawauchi, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462063/
https://www.ncbi.nlm.nih.gov/pubmed/32820036
http://dx.doi.org/10.1101/gad.337584.120

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