LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy

Somatic motor neurons are selectively vulnerable in spinal muscular atrophy (SMA), which is caused by a deficiency of the ubiquitously expressed survival of motor neuron protein. However, some motor neuron groups, including oculomotor and trochlear (ocular), which innervate eye muscles, are for unkn...

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Detalles Bibliográficos
Autores principales: Nichterwitz, Susanne, Nijssen, Jik, Storvall, Helena, Schweingruber, Christoph, Comley, Laura Helen, Allodi, Ilary, van der Lee, Mirjam, Deng, Qiaolin, Sandberg, Rickard, Hedlund, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462070/
https://www.ncbi.nlm.nih.gov/pubmed/32820007
http://dx.doi.org/10.1101/gr.265017.120

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