PR-DUB maintains the expression of critical genes through FOXK1/2- and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination

Polycomb group proteins are important for maintaining gene expression patterns and cell identity in metazoans. The mammalian Polycomb repressive deubiquitinase (PR-DUB) complexes catalyze removal of monoubiquitination on lysine 119 of histone H2A (H2AK119ub1) through a multiprotein core comprised of...

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Detalles Bibliográficos
Autores principales: Kolovos, Petros, Nishimura, Koutarou, Sankar, Aditya, Sidoli, Simone, Cloos, Paul A., Helin, Kristian, Christensen, Jesper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462075/
https://www.ncbi.nlm.nih.gov/pubmed/32747411
http://dx.doi.org/10.1101/gr.261016.120

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