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Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission

Although dysregulation of mitochondrial dynamics has been linked to cellular senescence, which contributes to advanced age-related disorders, it is unclear how Krüppel-like factor 5 (Klf5), an essential transcriptional factor of cardiovascular remodeling, mediates the link between mitochondrial dyna...

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Detalles Bibliográficos
Autores principales:	Ma, Dong, Zheng, Bin, Liu, He-liang, Zhao, Yong-bo, Liu, Xiao, Zhang, Xin-hua, Li, Qiang, Shi, Wei-bo, Suzuki, Toru, Wen, Jin-kun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462304/ https://www.ncbi.nlm.nih.gov/pubmed/32817651 http://dx.doi.org/10.1371/journal.pbio.3000808

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