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IFN-γ treatment protocol for MHC-I(lo)/PD-L1(+) pancreatic tumor cells selectively restores their TAP-mediated presentation competence and CD8 T-cell priming potential

BACKGROUND: Many cancer cells express a major histocompatibility complex class I low/ programmed cell death 1 ligand 1 positive (MHC-I(lo)/PD-L1(+)) cell surface profile. For immunotherapy, there is, thus, an urgent need to restore presentation competence of cancer cells with defects in MHC-I proces...

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Detalles Bibliográficos
Autores principales:	Stifter, Katja, Krieger, Jana, Ruths, Leonie, Gout, Johann, Mulaw, Medhanie, Lechel, Andre, Kleger, Alexander, Seufferlein, Thomas, Wagner, Martin, Schirmbeck, Reinhold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462314/ https://www.ncbi.nlm.nih.gov/pubmed/32868392 http://dx.doi.org/10.1136/jitc-2020-000692

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