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Mg(2+)-Dependent Methyl Transfer by a Knotted Protein: A Molecular Dynamics Simulation and Quantum Mechanics Study
[Image: see text] Mg(2+) is required for the catalytic activity of TrmD, a bacteria-specific methyltransferase that is made up of a protein topological knot-fold, to synthesize methylated m(1)G37-tRNA to support life. However, neither the location of Mg(2+) in the structure of TrmD nor its role in t...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462349/ https://www.ncbi.nlm.nih.gov/pubmed/32904895 http://dx.doi.org/10.1021/acscatal.0c00059 |