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Network topology of symbolic and nonsymbolic number comparison

Studies of brain activity during number processing suggest symbolic and nonsymbolic numerical stimuli (e.g., Arabic digits and dot arrays) engage both shared and distinct neural mechanisms. However, the extent to which number format influences large-scale functional network organization is unknown....

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Detalles Bibliográficos
Autores principales: Conrad, Benjamin N., Wilkey, Eric D., Yeo, Darren J., Price, Gavin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MIT Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462424/
https://www.ncbi.nlm.nih.gov/pubmed/32885123
http://dx.doi.org/10.1162/netn_a_00144
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author Conrad, Benjamin N.
Wilkey, Eric D.
Yeo, Darren J.
Price, Gavin R.
author_facet Conrad, Benjamin N.
Wilkey, Eric D.
Yeo, Darren J.
Price, Gavin R.
author_sort Conrad, Benjamin N.
collection PubMed
description Studies of brain activity during number processing suggest symbolic and nonsymbolic numerical stimuli (e.g., Arabic digits and dot arrays) engage both shared and distinct neural mechanisms. However, the extent to which number format influences large-scale functional network organization is unknown. In this study, using 7 Tesla MRI, we adopted a network neuroscience approach to characterize the whole-brain functional architecture supporting symbolic and nonsymbolic number comparison in 33 adults. Results showed the degree of global modularity was similar for both formats. The symbolic format, however, elicited stronger community membership among auditory regions, whereas for nonsymbolic, stronger membership was observed within and between cingulo-opercular/salience network and basal ganglia communities. The right posterior inferior temporal gyrus, left intraparietal sulcus, and two regions in the right ventromedial occipital cortex demonstrated robust differences between formats in terms of their community membership, supporting prior findings that these areas are differentially engaged based on number format. Furthermore, a unified fronto-parietal/dorsal attention community in the nonsymbolic condition was fractionated into two components in the symbolic condition. Taken together, these results reveal a pattern of overlapping and distinct network architectures for symbolic and nonsymbolic number processing.
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spelling pubmed-74624242020-09-02 Network topology of symbolic and nonsymbolic number comparison Conrad, Benjamin N. Wilkey, Eric D. Yeo, Darren J. Price, Gavin R. Netw Neurosci Research Articles Studies of brain activity during number processing suggest symbolic and nonsymbolic numerical stimuli (e.g., Arabic digits and dot arrays) engage both shared and distinct neural mechanisms. However, the extent to which number format influences large-scale functional network organization is unknown. In this study, using 7 Tesla MRI, we adopted a network neuroscience approach to characterize the whole-brain functional architecture supporting symbolic and nonsymbolic number comparison in 33 adults. Results showed the degree of global modularity was similar for both formats. The symbolic format, however, elicited stronger community membership among auditory regions, whereas for nonsymbolic, stronger membership was observed within and between cingulo-opercular/salience network and basal ganglia communities. The right posterior inferior temporal gyrus, left intraparietal sulcus, and two regions in the right ventromedial occipital cortex demonstrated robust differences between formats in terms of their community membership, supporting prior findings that these areas are differentially engaged based on number format. Furthermore, a unified fronto-parietal/dorsal attention community in the nonsymbolic condition was fractionated into two components in the symbolic condition. Taken together, these results reveal a pattern of overlapping and distinct network architectures for symbolic and nonsymbolic number processing. MIT Press 2020-08-01 /pmc/articles/PMC7462424/ /pubmed/32885123 http://dx.doi.org/10.1162/netn_a_00144 Text en © 2020 Massachusetts Institute of Technology This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For a full description of the license, please visit https://creativecommons.org/licenses/by/4.0/legalcode.
spellingShingle Research Articles
Conrad, Benjamin N.
Wilkey, Eric D.
Yeo, Darren J.
Price, Gavin R.
Network topology of symbolic and nonsymbolic number comparison
title Network topology of symbolic and nonsymbolic number comparison
title_full Network topology of symbolic and nonsymbolic number comparison
title_fullStr Network topology of symbolic and nonsymbolic number comparison
title_full_unstemmed Network topology of symbolic and nonsymbolic number comparison
title_short Network topology of symbolic and nonsymbolic number comparison
title_sort network topology of symbolic and nonsymbolic number comparison
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462424/
https://www.ncbi.nlm.nih.gov/pubmed/32885123
http://dx.doi.org/10.1162/netn_a_00144
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