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Reconfigurations within resonating communities of brain regions following TMS reveal different scales of processing
An overarching goal of neuroscience research is to understand how heterogeneous neuronal ensembles cohere into networks of coordinated activity to support cognition. To investigate how local activity harmonizes with global signals, we measured electroencephalography (EEG) while single pulses of tran...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MIT Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462427/ https://www.ncbi.nlm.nih.gov/pubmed/32885118 http://dx.doi.org/10.1162/netn_a_00139 |
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author | Garcia, Javier O. Ashourvan, Arian Thurman, Steven M. Srinivasan, Ramesh Bassett, Danielle S. Vettel, Jean M. |
author_facet | Garcia, Javier O. Ashourvan, Arian Thurman, Steven M. Srinivasan, Ramesh Bassett, Danielle S. Vettel, Jean M. |
author_sort | Garcia, Javier O. |
collection | PubMed |
description | An overarching goal of neuroscience research is to understand how heterogeneous neuronal ensembles cohere into networks of coordinated activity to support cognition. To investigate how local activity harmonizes with global signals, we measured electroencephalography (EEG) while single pulses of transcranial magnetic stimulation (TMS) perturbed occipital and parietal cortices. We estimate the rapid network reconfigurations in dynamic network communities within specific frequency bands of the EEG, and characterize two distinct features of network reconfiguration, flexibility and allegiance, among spatially distributed neural sources following TMS. Using distance from the stimulation site to infer local and global effects, we find that alpha activity (8–12 Hz) reflects concurrent local and global effects on network dynamics. Pairwise allegiance of brain regions to communities on average increased near the stimulation site, whereas TMS-induced changes to flexibility were generally invariant to distance and stimulation site. In contrast, communities within the beta (13–20 Hz) band demonstrated a high level of spatial specificity, particularly within a cluster comprising paracentral areas. Together, these results suggest that focal magnetic neurostimulation to distinct cortical sites can help identify both local and global effects on brain network dynamics, and highlight fundamental differences in the manifestation of network reconfigurations within alpha and beta frequency bands. |
format | Online Article Text |
id | pubmed-7462427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MIT Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74624272020-09-02 Reconfigurations within resonating communities of brain regions following TMS reveal different scales of processing Garcia, Javier O. Ashourvan, Arian Thurman, Steven M. Srinivasan, Ramesh Bassett, Danielle S. Vettel, Jean M. Netw Neurosci Research Articles An overarching goal of neuroscience research is to understand how heterogeneous neuronal ensembles cohere into networks of coordinated activity to support cognition. To investigate how local activity harmonizes with global signals, we measured electroencephalography (EEG) while single pulses of transcranial magnetic stimulation (TMS) perturbed occipital and parietal cortices. We estimate the rapid network reconfigurations in dynamic network communities within specific frequency bands of the EEG, and characterize two distinct features of network reconfiguration, flexibility and allegiance, among spatially distributed neural sources following TMS. Using distance from the stimulation site to infer local and global effects, we find that alpha activity (8–12 Hz) reflects concurrent local and global effects on network dynamics. Pairwise allegiance of brain regions to communities on average increased near the stimulation site, whereas TMS-induced changes to flexibility were generally invariant to distance and stimulation site. In contrast, communities within the beta (13–20 Hz) band demonstrated a high level of spatial specificity, particularly within a cluster comprising paracentral areas. Together, these results suggest that focal magnetic neurostimulation to distinct cortical sites can help identify both local and global effects on brain network dynamics, and highlight fundamental differences in the manifestation of network reconfigurations within alpha and beta frequency bands. MIT Press 2020-07-01 /pmc/articles/PMC7462427/ /pubmed/32885118 http://dx.doi.org/10.1162/netn_a_00139 Text en No rights reserved. This work was authored as part of the Contributors official duties as an Employee of the United States Government and is therefore the work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. law. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For a full description of the license, please visit https://creativecommons.org/licenses/by/4.0/legalcode. |
spellingShingle | Research Articles Garcia, Javier O. Ashourvan, Arian Thurman, Steven M. Srinivasan, Ramesh Bassett, Danielle S. Vettel, Jean M. Reconfigurations within resonating communities of brain regions following TMS reveal different scales of processing |
title | Reconfigurations within resonating communities of brain regions following TMS reveal different scales of processing |
title_full | Reconfigurations within resonating communities of brain regions following TMS reveal different scales of processing |
title_fullStr | Reconfigurations within resonating communities of brain regions following TMS reveal different scales of processing |
title_full_unstemmed | Reconfigurations within resonating communities of brain regions following TMS reveal different scales of processing |
title_short | Reconfigurations within resonating communities of brain regions following TMS reveal different scales of processing |
title_sort | reconfigurations within resonating communities of brain regions following tms reveal different scales of processing |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462427/ https://www.ncbi.nlm.nih.gov/pubmed/32885118 http://dx.doi.org/10.1162/netn_a_00139 |
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