Cargando…

Erythromycin Releasing PVA/sucrose and PVA/honey Hydrogels as Wound Dressings with Antibacterial Activity and Enhanced Bio-adhesion

The present study deals with preparation and characterization of thermally crosslinked PVA-based hydrogels containing honey and sucrose for the purpose of erythromycin delivery. The hydrogels have been characterized and compared by scanning electron microscopy, Fourier transform infrared spectroscop...

Descripción completa

Detalles Bibliográficos
Autores principales: Fathollahipour, Shahrzad, Koosha, Mojtaba, Tavakoli, Javad, Maziarfar, Susan, Fallah Mehrabadi, Jalil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462510/
https://www.ncbi.nlm.nih.gov/pubmed/32922500
http://dx.doi.org/10.22037/ijpr.2019.1101002
_version_ 1783576932197072896
author Fathollahipour, Shahrzad
Koosha, Mojtaba
Tavakoli, Javad
Maziarfar, Susan
Fallah Mehrabadi, Jalil
author_facet Fathollahipour, Shahrzad
Koosha, Mojtaba
Tavakoli, Javad
Maziarfar, Susan
Fallah Mehrabadi, Jalil
author_sort Fathollahipour, Shahrzad
collection PubMed
description The present study deals with preparation and characterization of thermally crosslinked PVA-based hydrogels containing honey and sucrose for the purpose of erythromycin delivery. The hydrogels have been characterized and compared by scanning electron microscopy, Fourier transform infrared spectroscopy, and bio-adhesion tests. Swelling measurements showed that addition of sucrose and honey decreased the equilibrium swelling of the hydrogels. Results of release studies showed that the amount of erythromycin, released at the early hours was higher for PVA/sucrose and PVA/honey hydrogels compared to PVA hydrogel while the drug released at later times was highly reduced for PVA/honey hydrogel. Both Peppas-Sahlin and Korsmeyer-Peppas models fitted well to the release data. Fitting Peppas-Sahlin model to the release data showed that at the initial times, release of drug from the hydrogel network was mainly governed by Fickian mechanism; however, at later times the drug is dominantly released by relaxational mechanism due to swelling of the network,. Addition of honey improved the bio-adhesion of PVA/honey hydrogel as compared to PVA/sucrose and pure PVA hydrogel. Results of antibacterial tests showed growth inhibitory action of erythromycin-loaded PVA hydrogels against Pseudomonas aeruginosa and Staphylococcus aureus bacteria. This study indicates that these hybrid hydrogels are capable of being used as functional wound dressings aiming to control the rate of antibiotic delivery to the wound site and prevent the wounds from infection.
format Online
Article
Text
id pubmed-7462510
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Shaheed Beheshti University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-74625102020-09-11 Erythromycin Releasing PVA/sucrose and PVA/honey Hydrogels as Wound Dressings with Antibacterial Activity and Enhanced Bio-adhesion Fathollahipour, Shahrzad Koosha, Mojtaba Tavakoli, Javad Maziarfar, Susan Fallah Mehrabadi, Jalil Iran J Pharm Res Original Article The present study deals with preparation and characterization of thermally crosslinked PVA-based hydrogels containing honey and sucrose for the purpose of erythromycin delivery. The hydrogels have been characterized and compared by scanning electron microscopy, Fourier transform infrared spectroscopy, and bio-adhesion tests. Swelling measurements showed that addition of sucrose and honey decreased the equilibrium swelling of the hydrogels. Results of release studies showed that the amount of erythromycin, released at the early hours was higher for PVA/sucrose and PVA/honey hydrogels compared to PVA hydrogel while the drug released at later times was highly reduced for PVA/honey hydrogel. Both Peppas-Sahlin and Korsmeyer-Peppas models fitted well to the release data. Fitting Peppas-Sahlin model to the release data showed that at the initial times, release of drug from the hydrogel network was mainly governed by Fickian mechanism; however, at later times the drug is dominantly released by relaxational mechanism due to swelling of the network,. Addition of honey improved the bio-adhesion of PVA/honey hydrogel as compared to PVA/sucrose and pure PVA hydrogel. Results of antibacterial tests showed growth inhibitory action of erythromycin-loaded PVA hydrogels against Pseudomonas aeruginosa and Staphylococcus aureus bacteria. This study indicates that these hybrid hydrogels are capable of being used as functional wound dressings aiming to control the rate of antibiotic delivery to the wound site and prevent the wounds from infection. Shaheed Beheshti University of Medical Sciences 2020 /pmc/articles/PMC7462510/ /pubmed/32922500 http://dx.doi.org/10.22037/ijpr.2019.1101002 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Fathollahipour, Shahrzad
Koosha, Mojtaba
Tavakoli, Javad
Maziarfar, Susan
Fallah Mehrabadi, Jalil
Erythromycin Releasing PVA/sucrose and PVA/honey Hydrogels as Wound Dressings with Antibacterial Activity and Enhanced Bio-adhesion
title Erythromycin Releasing PVA/sucrose and PVA/honey Hydrogels as Wound Dressings with Antibacterial Activity and Enhanced Bio-adhesion
title_full Erythromycin Releasing PVA/sucrose and PVA/honey Hydrogels as Wound Dressings with Antibacterial Activity and Enhanced Bio-adhesion
title_fullStr Erythromycin Releasing PVA/sucrose and PVA/honey Hydrogels as Wound Dressings with Antibacterial Activity and Enhanced Bio-adhesion
title_full_unstemmed Erythromycin Releasing PVA/sucrose and PVA/honey Hydrogels as Wound Dressings with Antibacterial Activity and Enhanced Bio-adhesion
title_short Erythromycin Releasing PVA/sucrose and PVA/honey Hydrogels as Wound Dressings with Antibacterial Activity and Enhanced Bio-adhesion
title_sort erythromycin releasing pva/sucrose and pva/honey hydrogels as wound dressings with antibacterial activity and enhanced bio-adhesion
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462510/
https://www.ncbi.nlm.nih.gov/pubmed/32922500
http://dx.doi.org/10.22037/ijpr.2019.1101002
work_keys_str_mv AT fathollahipourshahrzad erythromycinreleasingpvasucroseandpvahoneyhydrogelsaswounddressingswithantibacterialactivityandenhancedbioadhesion
AT kooshamojtaba erythromycinreleasingpvasucroseandpvahoneyhydrogelsaswounddressingswithantibacterialactivityandenhancedbioadhesion
AT tavakolijavad erythromycinreleasingpvasucroseandpvahoneyhydrogelsaswounddressingswithantibacterialactivityandenhancedbioadhesion
AT maziarfarsusan erythromycinreleasingpvasucroseandpvahoneyhydrogelsaswounddressingswithantibacterialactivityandenhancedbioadhesion
AT fallahmehrabadijalil erythromycinreleasingpvasucroseandpvahoneyhydrogelsaswounddressingswithantibacterialactivityandenhancedbioadhesion