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Synthesis of Flower-like Nickel Hydroxide Nanosheets and Application in Electrochemical Determination of Famotidine
An electrochemical sensor was designed and fabricated for electrocatalytic oxidation and determination of famotidine in pharmaceutical forms. The electrochemical oxidation process and its kinetics were investigated using cyclic voltammetry, steady-state polarization measurements, and chronoamperomet...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462516/ https://www.ncbi.nlm.nih.gov/pubmed/32922475 http://dx.doi.org/10.22037/ijpr.2019.14257.12245 |
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author | Dehdari Vais, Rezvan Yadegari, Hossein Heli, Hossein |
author_facet | Dehdari Vais, Rezvan Yadegari, Hossein Heli, Hossein |
author_sort | Dehdari Vais, Rezvan |
collection | PubMed |
description | An electrochemical sensor was designed and fabricated for electrocatalytic oxidation and determination of famotidine in pharmaceutical forms. The electrochemical oxidation process and its kinetics were investigated using cyclic voltammetry, steady-state polarization measurements, and chronoamperometry techniques, and also the analytical measurements were performed by amperometry. Upon addition of the drug into the solution, cyclic voltammograms of the fabricated sensor exhibited an increased anodic peak current associated with a decrease in the corresponding cathodic current. These results suggested an electrocatalytic EC’ oxidation mechanism for famotidine on the oxyhydroxide species immobilized on the electrode surface. Accordingly, a mechanism involving generation of Ni(3+) active sites and their subsequent consumption by the drug was proposed. Moreover, the corresponding rate law under the control of charge transfer was developed and kinetic parameters were derived. A sensitive and time-saving amperometric procedure was also developed for the analysis of famotidine with a detection limit of 5.91 mmol L(-1). Using the developed amperometric procedure, famotidine was successfully analyzed in the presence of ibuprofen. The developed sensor in this study displayed enhanced sensitivity and selectivity, compared to some other reported methods. |
format | Online Article Text |
id | pubmed-7462516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-74625162020-09-11 Synthesis of Flower-like Nickel Hydroxide Nanosheets and Application in Electrochemical Determination of Famotidine Dehdari Vais, Rezvan Yadegari, Hossein Heli, Hossein Iran J Pharm Res Original Article An electrochemical sensor was designed and fabricated for electrocatalytic oxidation and determination of famotidine in pharmaceutical forms. The electrochemical oxidation process and its kinetics were investigated using cyclic voltammetry, steady-state polarization measurements, and chronoamperometry techniques, and also the analytical measurements were performed by amperometry. Upon addition of the drug into the solution, cyclic voltammograms of the fabricated sensor exhibited an increased anodic peak current associated with a decrease in the corresponding cathodic current. These results suggested an electrocatalytic EC’ oxidation mechanism for famotidine on the oxyhydroxide species immobilized on the electrode surface. Accordingly, a mechanism involving generation of Ni(3+) active sites and their subsequent consumption by the drug was proposed. Moreover, the corresponding rate law under the control of charge transfer was developed and kinetic parameters were derived. A sensitive and time-saving amperometric procedure was also developed for the analysis of famotidine with a detection limit of 5.91 mmol L(-1). Using the developed amperometric procedure, famotidine was successfully analyzed in the presence of ibuprofen. The developed sensor in this study displayed enhanced sensitivity and selectivity, compared to some other reported methods. Shaheed Beheshti University of Medical Sciences 2020 /pmc/articles/PMC7462516/ /pubmed/32922475 http://dx.doi.org/10.22037/ijpr.2019.14257.12245 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Dehdari Vais, Rezvan Yadegari, Hossein Heli, Hossein Synthesis of Flower-like Nickel Hydroxide Nanosheets and Application in Electrochemical Determination of Famotidine |
title | Synthesis of Flower-like Nickel Hydroxide Nanosheets and Application in Electrochemical Determination of Famotidine |
title_full | Synthesis of Flower-like Nickel Hydroxide Nanosheets and Application in Electrochemical Determination of Famotidine |
title_fullStr | Synthesis of Flower-like Nickel Hydroxide Nanosheets and Application in Electrochemical Determination of Famotidine |
title_full_unstemmed | Synthesis of Flower-like Nickel Hydroxide Nanosheets and Application in Electrochemical Determination of Famotidine |
title_short | Synthesis of Flower-like Nickel Hydroxide Nanosheets and Application in Electrochemical Determination of Famotidine |
title_sort | synthesis of flower-like nickel hydroxide nanosheets and application in electrochemical determination of famotidine |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462516/ https://www.ncbi.nlm.nih.gov/pubmed/32922475 http://dx.doi.org/10.22037/ijpr.2019.14257.12245 |
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