Cargando…

Disruption of the ERLIN–TM6SF2–APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder characterized by excess lipid accumulation in the liver without significant consumption of alcohol. The transmembrane 6 superfamily member 2 (TM6SF2) E167K missense variant strongly associates with NAFLD in humans. The E167K mutation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Bo-Tao, Sun, Ming, Li, Yun-Feng, Wang, Ju-Qiong, Zhou, Zi-Mu, Song, Bao-Liang, Luo, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462549/ https://www.ncbi.nlm.nih.gov/pubmed/32776921 http://dx.doi.org/10.1371/journal.pgen.1008955

Ejemplares similares

Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2
por: Pott, Janne, et al.
Publicado: (2021)

Mucosal Tolerance to a Combination of ApoB and HSP60 Peptides Controls Plaque Progression and Stabilizes Vulnerable Plaque in Apob(tm2Sgy)Ldlr(tm1Her)/J Mice
por: Mundkur, Lakshmi, et al.
Publicado: (2013)

Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice
por: Thota, Lakshmi Narasimha, et al.
Publicado: (2017)

Investigation of human apoB48 metabolism using a new, integrated non‐steady‐state model of apoB48 and apoB100 kinetics
por: Björnson, E., et al.
Publicado: (2019)

Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
por: Khoo, Bernard, et al.
Publicado: (2007)

Associations of the APOB rs693 and rs17240441 polymorphisms with plasma APOB and lipid levels: a meta-analysis
por: Niu, Caiqin, et al.
Publicado: (2017)

Author Correction: Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice
por: Thota, Lakshmi Narasimha, et al.
Publicado: (2018)

Clinical significance of APOB inactivation in hepatocellular carcinoma
por: Lee, Gena, et al.
Publicado: (2018)

Regulation of plasma LDL: the apoB paradigm
por: Sniderman, Allan D., et al.
Publicado: (2009)

The Enzymatic Activity of APOBE3G Multimers
por: Pan, Yangang, et al.
Publicado: (2018)

Serum ApoB levels in depressive patients: associated with cognitive deficits
por: Hui, Li, et al.
Publicado: (2017)

Cerebrovascular Pathology in Hypertriglyceridemic APOB-100 Transgenic Mice
por: Hoyk, Zsófia, et al.
Publicado: (2018)

Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults
por: Hochner, Hagit, et al.
Publicado: (2015)

ApoB48 as an Efficient Regulator of Intestinal Lipid Transport
por: Lo, Chunmin C., et al.
Publicado: (2020)

A Comparison of Lipids and apoB in Asian Indians and Americans
por: Singh, Kavita, et al.
Publicado: (2021)

Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population
por: Gu, Q-L., et al.
Publicado: (2017)

HBV inhibits apoB production via the suppression of MTP expression
por: Wang, Fu-Bing, et al.
Publicado: (2011)

SAA is Found on ApoB-Containing Lipoproteins in Obese Diabetic Humans
por: Jahangiri, Anisa, et al.
Publicado: (2013)

The APOB gene polymorphism in the pathogenesis of gallstone disease in pre- and postmenopausal women
por: Rudzińska, Karolina, et al.
Publicado: (2015)

The Study of rs693 and rs515135 in APOB in People with Familial Hypercholestrolemia
por: Karami, Fatemeh, et al.
Publicado: (2019)

ApoB-Specific CD4(+) T Cells in Mouse and Human Atherosclerosis
por: Marchini, Timoteo, et al.
Publicado: (2021)

Identification and Functional Analysis of APOB Variants in a Cohort of Hypercholesterolemic Patients
por: Rodríguez-Jiménez, Carmen, et al.
Publicado: (2023)

Uptake of (68)gallium in atherosclerotic plaques in LDLR(-/-)ApoB(100/100 )mice
por: Silvola, Johanna MU, et al.
Publicado: (2011)

Human apoB contributes to increased serum total apo(a) level in LPA transgenic mice
por: Teivainen, Päivi A, et al.
Publicado: (2004)

Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100
por: Tse, Kevin, et al.
Publicado: (2013)

A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle
por: Menzi, F., et al.
Publicado: (2016)

Relationship Between Adiponectin and apoB in Individuals With Diabetes in the Atlantic PATH Cohort
por: DeClercq, Vanessa, et al.
Publicado: (2017)

Increased Risk of the APOB rs11279109 Polymorphism for CHD among the Kuwaiti Population
por: Al-Bustan, Suzanne A., et al.
Publicado: (2017)

Identification of apoB‐100 Peptide‐Specific CD8+ T Cells in Atherosclerosis
por: Dimayuga, Paul C., et al.
Publicado: (2017)

The APOB rs693 polymorphism impacts the lipid profile of Brazilian older adults
por: Alves, E.S., et al.
Publicado: (2020)

A Rare Mutation in The APOB Gene Associated with Neurological Manifestations in Familial Hypobetalipoproteinemia
por: Musialik, Joanna, et al.
Publicado: (2020)

Biphasic Production of Anti-ApoB100 Autoantibodies in Obese Humans and Mice
por: Choe, Moon Kyung, et al.
Publicado: (2021)

The LDLR, APOB, and PCSK9 Variants of Index Patients with Familial Hypercholesterolemia in Russia
por: Meshkov, Alexey, et al.
Publicado: (2021)

Immunization using ApoB-100 peptide–linked nanoparticles reduces atherosclerosis
por: Chyu, Kuang-Yuh, et al.
Publicado: (2022)

The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults
por: Vimaleswaran, Karani Santhanakrishnan, et al.
Publicado: (2015)

Immunization of Chlamydia pneumoniae (Cpn)-Infected Apob(tm2Sgy)Ldlr(tm1Her)/J Mice with a Combined Peptide of Cpn Significantly Reduces Atherosclerotic Lesion Development
por: Xia, Min, et al.
Publicado: (2013)

ApoB siRNA-induced Liver Steatosis is Resistant to Clearance by the Loss of Fatty Acid Transport Protein 5 (Fatp5)
por: Ason, Brandon, et al.
Publicado: (2011)

Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation
por: Lin, Huige, et al.
Publicado: (2022)

The LDL-C/ApoB ratio predicts cardiovascular and all-cause mortality in the general population
por: Xiao, Li, et al.
Publicado: (2023)

Genetic association of APOB polymorphisms with variation in serum lipid profile among the Kuwait population
por: Al-Bustan, Suzanne A, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rfevksct2en3b0jbit5886jk3b