Cargando…

β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells

The β-catenin transcriptional coregulator is involved in various biological and pathological processes; however, its requirements in hematopoietic cells remain controversial. We re-targeted the Ctnnb1 gene locus to generate a true β-catenin-null mutant mouse strain. Ablation of β-catenin alone, or i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Xin, Shao, Peng, Gai, Kexin, Li, Fengyin, Shan, Qiang, Xue, Hai-Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462606/ https://www.ncbi.nlm.nih.gov/pubmed/32820720 http://dx.doi.org/10.7554/eLife.55360

Ejemplares similares

Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development
por: Fujimori, Sayumi, et al.
Publicado: (2022)

The effect of strontium ranelate on titanium particle-induced periprosthetic osteolysis regulated by WNT/β-catenin signaling in vivo and in vitro
por: Wang, Bolun, et al.
Publicado: (2021)

β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
por: Cobas, Monica, et al.
Publicado: (2004)

Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling
por: Feng, Xing, et al.
Publicado: (2023)

γ-Catenin Overexpression in AML Patients May Promote Tumor Cell Survival via Activation of the Wnt/β-Catenin Axis
por: Qian, Jiejin, et al.
Publicado: (2020)

Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain
por: Kovacs, Michael A, et al.
Publicado: (2022)

β-catenin induces expression of prohibitin gene in acute leukemic cells
por: Kim, Dong Min, et al.
Publicado: (2017)

IFN-γ mediates Paneth cell death via suppression of mTOR
por: Araujo, Alessandra, et al.
Publicado: (2021)

FcγRIIB-I232T polymorphic change allosterically suppresses ligand binding
por: Hu, Wei, et al.
Publicado: (2019)

Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes
por: Brenes, Alejandro J, et al.
Publicado: (2021)

Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation
por: Kolb, Philipp, et al.
Publicado: (2021)

Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells
por: Jensen, Isaac J, et al.
Publicado: (2021)

Neutrophil and lymphocyte counts are associated with different immunopathological mechanisms in systemic lupus erythematosus
por: Han, Bobby Kwanghoon, et al.
Publicado: (2020)

SARS-CoV-2 uses CD4 to infect T helper lymphocytes
por: Brunetti, Natalia S, et al.
Publicado: (2023)

A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation
por: Kiritsy, Michael C, et al.
Publicado: (2021)

Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation
por: Austin, Sophie H. L., et al.
Publicado: (2021)

Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma
por: Murata, Kenji, et al.
Publicado: (2020)

Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT
por: Baliu-Piqué, Mariona, et al.
Publicado: (2021)

Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis
por: Danzer, Heike, et al.
Publicado: (2020)

IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii
por: Clark, Joseph T, et al.
Publicado: (2021)

Interplay of Opposing Effects of the WNT/β-Catenin Pathway and PPARγ and Implications for SARS-CoV2 Treatment
por: Vallée, Alexandre, et al.
Publicado: (2021)

Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata
por: Laufer Britva, Rimma, et al.
Publicado: (2023)

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family
por: Chiarella, Sergio E., et al.
Publicado: (2018)

Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse
por: Chitirala, Praneeth, et al.
Publicado: (2020)

IFNγ induces epigenetic programming of human T-bet(hi) B cells and promotes TLR7/8 and IL-21 induced differentiation
por: Zumaquero, Esther, et al.
Publicado: (2019)

Protective function and durability of mouse lymph node-resident memory CD8(+) T cells
por: Anthony, Scott M, et al.
Publicado: (2021)

Ectopic γ-catenin Expression Partially Mimics the Effects of Stabilized β-catenin on Embryonic Stem Cell Differentiation
por: Mahendram, Sujeivan, et al.
Publicado: (2013)

Considering autophagy, β-Catenin and E-Cadherin as innovative therapy aspects in AML
por: Kühn, K, et al.
Publicado: (2015)

The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes
por: Serroukh, Yasmina, et al.
Publicado: (2018)

Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model
por: Fukasawa, Takemichi, et al.
Publicado: (2021)

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology
por: Gawish, Riem, et al.
Publicado: (2022)

γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin
por: Morgan, R G, et al.
Publicado: (2013)

IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25(+)Foxp3(-) T cells
por: Tomala, Jakub, et al.
Publicado: (2021)

Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies
por: Rawle, Daniel J, et al.
Publicado: (2022)

Wnt/β-Catenin Signaling as a Molecular Target by Pathogenic Bacteria
por: Silva-García, Octavio, et al.
Publicado: (2019)

NAD(+) attenuates experimental autoimmune encephalomyelitis through induction of CD11b(+) gr-1(+) myeloid-derived suppressor cells
por: Wang, Jin-Li, et al.
Publicado: (2020)

Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization
por: Ma, Wenxin, et al.
Publicado: (2019)

Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α
por: Li, Yu-Tung, et al.
Publicado: (2019)

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
por: Colombo, Alessio Vittorio, et al.
Publicado: (2021)

SMAD4 and TGFβ are architects of inverse genetic programs during fate determination of antiviral CTLs
por: Chandiran, Karthik, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gmj6ksbnu2l1nmjhdg8mvl5p5k