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What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?

Dopamine and striatal dysfunctions play a key role in the pathophysiology of Parkinson’s disease (PD) and Dystonia, but our understanding of the changes in the discharge rate and pattern of striatal projection neurons (SPNs) remains limited. Here, we recorded and examined multi-unit signals from the...

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Detalles Bibliográficos
Autores principales: Valsky, Dan, Heiman Grosberg, Shai, Israel, Zvi, Boraud, Thomas, Bergman, Hagai, Deffains, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462612/
https://www.ncbi.nlm.nih.gov/pubmed/32812870
http://dx.doi.org/10.7554/eLife.57445